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Tubulysin 

目录号: HY-128914
产品使用指南

Tubulysin 家族的次级代谢产物最初是从粘细菌 Archangium geophyraAngiococcus disciformis 中分离出来的。 这些化合物是有效的微管去稳定剂,其皮摩尔范围内的 IC50 值对抗许多包括具有多药抗性的癌细胞系。Tubulysins 由于严重毒性而具有有限的治疗效用,Tubulysins 是结合到小分子药物缀合物 (SMDC) 递送系统中的理想候选者。

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Tubulysin Chemical Structure

Tubulysin Chemical Structure

CAS No. : 1943604-24-7

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Description

Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system[1].

Molecular Weight

842.10

Formula

C₄₄H₆₇N₅O₉S

CAS No.

1943604-24-7

SMILES

O=C(O)[C@@H](C)C[C@@H](NC(C1=CSC([C@H](OC(C)=O)C[C@@H](N(COC(CC(C)C)=O)C([C@@H](NC([C@@H]2N(C)CCCC2)=O)[C@@H](C)CC)=O)C(C)C)=N1)=O)CC3=CC=C(C)C=C3

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Tubulysin
目录号:
HY-128914
需求量:

Tubulysin

Cat. No.: HY-128914