2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Tyrosine kinase-IN-7

Tyrosine kinase-IN-7 

目录号: HY-156912 纯度: 99.25%
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摩尔计算器

Tyrosine kinase-IN-7 (compound 13h) 是酪氨酸激酶 EGFR 抑制剂，抑制 EGFR(WT) 和 EGFR(T790M) 的 IC50s 分别为 0.630 μM，0.956 μM。Tyrosine kinase-IN-7 对四种癌细胞系（HepG2、HCT-116、MCF-7 和 A431）具有抗肿瘤活性，IC50s 分别为 13.02 μM，10.14 μM，12.68 μM，和 47.05 μM。

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Tyrosine kinase-IN-7 Chemical Structure

Tyrosine kinase-IN-7 Chemical Structure

CAS No. : 345615-74-9

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Tyrosine kinase-IN-7 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1].

IC50 & Target

IC50: 0.630 μM (EGFRWT), 0.956 μM (EGFRT790M)[1]
分子量

297.37

Formula

C16H15N3OS
CAS 号
性状

固体

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Tyrosine kinase-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Tyrosine kinase-IN-7345615-74-9EGFREpidermal growth factor receptorErbB-1HER1AnticancerApoptosisDockingEGFR(T790M)EGFR(WT)EGFR-TKHER2Thieno[2,3-d]pyrimidineInhibitorinhibitorinhibit

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