2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Endogenous Metabolite Estrogen Receptor/ERR
  4. 2-Hydroxyestrone

2-Hydroxyestrone  (Synonyms: Catecholestrone)

目录号: HY-113251
产品使用指南

摩尔计算器

2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

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2-Hydroxyestrone Chemical Structure

2-Hydroxyestrone Chemical Structure

CAS No. : 362-06-1

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规格 价格 是否有货 数量
1 mg ￥5180
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Customer Review

Other Forms of 2-Hydroxyestrone:

2-Hydroxyestrone 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

Estrogen receptor

 

体外研究
(In Vitro)

2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Hydroxyestrone 相关抗体:

Cell Proliferation Assay[2]

Cell Line: Human breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-330
Concentration: 1-1000 nM
Incubation Time: 6 days
Result: 10 and 100 nM markedly suppressed the growth and proliferation of the cells in the presence of quinalizarin. The tumor cell growth-inhibitory action of the catechol estrogen was neutralized by the presence of 1 nM estradiol.
体内研究
(In Vivo)

Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.) and  2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female and male Sprague-Dawley rats (6 weeks old)[3]
Dosage: 2 mg/kg
Administration: Administered i.p.
Result: Levels of both 2-OHE1 and  2-OHE1 4SR in rats treated with 2-OHE1 were significantly different between the induced and noninduced groups.
分子量

286.37

Formula

C18H22O3
CAS 号
中文名称

2-羟雌甾酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    2-Hydroxyestrone is suspended in corn oil by sonication[3].

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

2-Hydroxyestrone 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Hydroxyestrone362-06-1Catecholestrone2-羟雌甾酮Endogenous MetaboliteEstrogen Receptor/ERRanticarcinogenicantiestrogenicInhibitorinhibitorinhibit

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产品名称：
2-Hydroxyestrone
目录号：
HY-113251
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