2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Abicipar pegol

Abicipar pegol  (Synonyms: AGN-150998; MP0112)

目录号: HY-P99416

摩尔计算器

Abicipar pegol (AGN-150998, MP0112) 是一种抗 VEGF DARPin分子，DARPin 分子是一类新型的小蛋白，含有工程化的 ankyrin 重复结构域，以高特异性和亲和力与靶蛋白结合。Abicipar pegol 可有效抑制血管生成和血管通透性，通过玻璃体内注射，降低平均视网膜厚度和渗漏面积，用于眼部炎症等相关疾病研究。

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Abicipar pegol Chemical Structure

Abicipar pegol Chemical Structure

CAS No. : 1327278-94-3

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Abicipar pegol 相关抗体

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  • 参考文献

生物活性

Abicipar pegol (AGN-150998, MP0112) is an anti-VEGF DARPin molecule, a novel class of small proteins containing ankyrin repeat domains engineered to bind with high specificity and affinity to target proteins. Abicipar pegol effectively inhibits angiogenesis and vascular permeability and is used in the study of diseases related to ocular inflammation by intravitreal injection, reducing mean retinal thickness and leakage area[1][2].

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参考文献

Abicipar pegol 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abicipar pegol1327278-94-3AGN-150998 MP0112AGN150998AGN 150998MP0112MP 0112MP-0112VEGFRVascular endothelial growth factor receptorVEGFDARPinangiogenesisvascular permeabilityocular inflammationInhibitorinhibitorinhibit

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