2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. AC-42 hydrochloride

AC-42 hydrochloride 是 AC-42 (HY-118806) 的盐酸盐形式。AC-42 hydrochloride 是毒蕈碱 M1 受体 (muscarinic M1 receptor) 的变构激动剂，对人类野生型和 Y381A 突变型 M1 受体的 EC50 分别为 805 nM 和 220 nM。AC-42 hydrochloride 可刺激 CHO 细胞中的肌醇磷酸酯 (IP) 积累和钙动员。

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AC-42 hydrochloride

AC-42 hydrochloride Chemical Structure

CAS No. : 447407-36-5

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规格 价格 是否有货 数量
5 mg ￥1119
In-stock
10 mg ￥1950
In-stock
50 mg   询价  
100 mg   询价  

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Other Forms of AC-42 hydrochloride:

AC-42 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.21 μM
Compound: AC-42
Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
HEK293 EC50
0.45 μM
Compound: AC-42
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
HEK293 EC50
0.72 μM
Compound: AC-42
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
HEK293 EC50
0.74 μM
Compound: AC-42
Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay
[PMID: 22329602]
分子量

337.93

Formula

C20H32ClNO
CAS 号
性状

固体

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (147.96 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9592 mL 14.7960 mL 29.5919 mL
5 mM 0.5918 mL 2.9592 mL 5.9184 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

AC-42 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9592 mL 14.7960 mL 29.5919 mL 73.9798 mL
5 mM 0.5918 mL 2.9592 mL 5.9184 mL 14.7960 mL
10 mM 0.2959 mL 1.4796 mL 2.9592 mL 7.3980 mL
15 mM 0.1973 mL 0.9864 mL 1.9728 mL 4.9320 mL
20 mM 0.1480 mL 0.7398 mL 1.4796 mL 3.6990 mL
25 mM 0.1184 mL 0.5918 mL 1.1837 mL 2.9592 mL
30 mM 0.0986 mL 0.4932 mL 0.9864 mL 2.4660 mL
40 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8495 mL
50 mM 0.0592 mL 0.2959 mL 0.5918 mL 1.4796 mL
60 mM 0.0493 mL 0.2466 mL 0.4932 mL 1.2330 mL
80 mM 0.0370 mL 0.1849 mL 0.3699 mL 0.9247 mL
100 mM 0.0296 mL 0.1480 mL 0.2959 mL 0.7398 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-42447407-36-5AC42AC 42mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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产品名称：
AC-42 hydrochloride
目录号：
HY-118806A
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