2. Apoptosis Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR
  3. Apoptosis VEGFR ERK Akt Caspase Bcl-2 Family
  4. AC-P19M

AC-P19M 是一种抗癌肽。AC-P19M 通过破坏癌细胞膜诱导细胞凋亡 (apoptosis)。AC-P19M 可逆转上皮-间质转化 (EMT)。AC-P19M 通过抑制 VEGF-VEGFR2/ERK/Akt 信号通路发挥抗血管生成活性。AC-P19M 可用于肺癌的相关研究。

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Custom Peptide Synthesis

AC-P19M

AC-P19M Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

AC-P19M 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AC-P19M is an anticancer peptide. AC-P19M induces apoptosis by disrupting the cell membrane of cancer cells. AC-P19M reverses epithelial-mesenchymal transition (EMT). AC-P19M shows anti-angiogenic activity through the inhibition of VEGF-VEGFR2/ERK/Akt signaling. AC-P19M can be used for lung cancer research[1].

体外研究
(In Vitro)

AC-P19M (0.1-100 μM，24 小时) 对肺癌细胞 (A549 和 H460) 表现出强效的抗癌活性，同时对正常细胞 (BEAS-2B) 和红细胞的毒性较低[1]。
AC-P19M (0.1-100 μM，6 小时) 可诱导 A549 和 H460 细胞释放乳酸脱氢酶 (LDH)，表明其破坏细胞膜，导致细胞死亡[1]。
AC-P19M (2-10 μM，24 小时) 可通过 Bcl-2/Bax/caspase 3 信号通路诱导 A549 和 H460 细胞凋亡[1]。
AC-P19M (0.2-0.5 μM，24 小时) 通过逆转间质特性和 EMT 标志物的表达，抑制 A549 和 H460 细胞的迁移和侵袭，最终抑制上皮间质转化 (EMT) 过程[1]。
AC-P19M (10 μM，12 小时) 通过减少人脐静脉内皮细胞 (HUVEC) 的管状形态，同时抑制 VEGF-VEGFR2/ERK/Akt 信号通路，发挥抗血管生成作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AC-P19M 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 and H460 cells
Concentration: 0.2, 0.5, 2, 5, and 10 μM
Incubation Time: 24 h
Result: Significantly decreased Bcl-2 levels, showing almost no expression at 10 μM.
Upregulated Bax protein levels to 2.5-fold in a concentration-dependent manner.
Resulted in a more than 2-fold increase of caspase 3.
Increased the expression levels of E-cadherin, while decreased the expression levels of N-cadherin and vimentin.

Cell Migration Assay [1]

Cell Line: A549 and H460 cells
Concentration: 0.2 and 0.5 μM
Incubation Time: 24 h
Result: Inhibited cell migration by more than 20% in both A549 and H460 cells.

Cell Invasion Assay[1]

Cell Line: A549 and H460 cells
Concentration: 0.2 and 0.5 μM
Incubation Time: 24 h
Result: Inhibited cell invasion by more than 20% in both A549 and H460 cells.
分子量

2096.73

Formula

C102H186N26O20
Sequence

Phe-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Lys-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Leu-Ala-Leu
Sequence Shortening

FAKKLAKLKKKLAKLALA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AC-P19M 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-P19MApoptosisVEGFRERKAktCaspaseBcl-2 FamilyVascular endothelial growth factor receptorExtracellular signal regulated kinasesPKBProtein kinase Banticancer peptideepithelial-mesenchymalanti-angiogenicVEGFR2lung cancerA549H460BEAS-2BHUVECsVEGF-VEGFR2/ERK/AktInhibitorinhibitorinhibit

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目录号：
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