1. Others Anti-infection Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  2. Isotope-Labeled Compounds HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
  3. Atazanavir-d9

Atazanavir-d9  (Synonyms: 阿扎那韦-d9; BMS-232632-d9)

目录号: HY-17367S2
产品使用指南

Atazanavir-d9 是 Atazanavir 的氘代物。Atazanavir (BMS-232632) 是一种高选择性的 HIV-1蛋白酶抑制剂,用于艾滋病毒感染的研究。Atazanavir 是 CYP3A4 的底物和抑制剂,也是 P-糖蛋白的抑制剂和诱导剂。Atazanavir 也是 SARS-CoV 3CLpro 的抑制剂,IC50 为 3.49 μM。

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Atazanavir-d<sub>9</sub> Chemical Structure

Atazanavir-d9 Chemical Structure

CAS No. : 1092540-51-6

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生物活性

Atazanavir-d9 is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

713.91

Formula

C38H43D9N6O7

CAS 号
中文名称

阿扎那韦-d9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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