2. Anti-infection Immunology/Inflammation Apoptosis MAPK/ERK Pathway NF-κB
  3. Bacterial Toll-like Receptor (TLR) TNF Receptor Interleukin Related JNK NF-κB
  4. Cathelicidin-PY

Cathelicidin-PY 是一种具有强抗菌 (antimicrobial) 活性的抗菌肽。Cathelicidin-PY 可抑制脂多糖 (LPS) (HY-D1056) 诱导的 TLR4 炎症反应通路的激活。Cathelicidin-PY 具有很强的抗菌和抗炎活性，且对 RAW 264.7 细胞的细胞毒性较低。Cathelicidin-PY 可用于抗菌和抗炎研究。

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Custom Peptide Synthesis

Cathelicidin-PY

Cathelicidin-PY Chemical Structure

CAS No. : 1431866-92-0

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Cathelicidin-PY 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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JNK1 JNK2 JNK3 JNK

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cathelicidin-PY is an antimicrobial peptide exhibiting strong antimicrobial property. Cathelicidin-PY inhibits the activation of TLR4 inflammatory response pathways induced by lipopolysaccharide (LPS) (HY-D1056). Cathelicidin-PY possesses strong antimicrobial and anti-inflammatory activities and low cytotoxic ability against RAW 264.7 cells. Cathelicidin-PY can be used for antimicrobial and anti-inflammatory research[1].

体外研究
(In Vitro)

Cathelicidin-PY 对大多数受试微生物具有强效抗菌活性，其最低抑菌浓度 (MIC) 为 4.69-37.5 μg/mL，且对临床分离的耐药菌株和标准菌株均表现出相同的抗菌活性[1]。
Cathelicidin-PY (2.5-20 μg/mL，24 小时) 通过抑制一氧化氮 (NO) 和炎症细胞因子 (如 TNF-α、IL-6 和单核细胞趋化蛋白 -1 (MCP-1)) 的产生发挥抗炎活性[1]。
Cathelicidin-PY (5-20 μg/mL，1 小时) 通过剂量依赖性地下调 TLR4 表达、抑制 JNK 活化、阻止 NF-κB p65 核转位，抑制 RAW 264.7 小鼠巨噬细胞中 LPS 诱导的 TLR4 信号通路[1]。
Cathelicidin-PY (1×MIC，30 分钟) 可诱导大肠杆菌细胞膜紊乱，表现为膜破裂、细胞内含物外流和细胞边界模糊[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cathelicidin-PY 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW 264.7 murine macrophage cells
Concentration: 0, 5, 10, and 20 μg/mL
Incubation Time: 1 h
Result: Inhibited the expression of TLR4, JNK, and the translocation of NF-κB from cytoplasm to nucleus in a dose-dependent manner.
Inhibited 85% TLR4 expression and 74% NF-κB translocation induced by LPS (100 ng/mL, 3 h) at the concentration of 20 μg/mL, respectively.
Inhibited JNK expression induced by LPS.
Completely blocked LPS-induced JNK2 expression at 10 or 20 μg/mL.
分子量

3425.13

Formula

C151H263N47O39S2
CAS 号
Sequence

Arg-Lys-Cys-Asn-Phe-Leu-Cys-Lys-Leu-Lys-Glu-Lys-Leu-Arg-Thr-Val-Ile-Thr-Ser-His-Ile-Asp-Lys-Val-Leu-Arg-Pro-Gln-Gly
Sequence Shortening

RKCNFLCKLKEKLRTVITSHIDKVLRPQG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cathelicidin-PY 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cathelicidin-PY1431866-92-0BacterialToll-like Receptor (TLR)TNF ReceptorInterleukin RelatedJNKNF-κBTumor Necrosis Factor ReceptorTNFRILc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBantimicrobial peptidebacterial membranesRAW 264.7 cellsanti-inflammatoryTLR4Inhibitorinhibitorinhibit

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