2. NF-κB Apoptosis Immunology/Inflammation
  3. NF-κB TNF Receptor Interleukin Related
  4. CAY10512

CAY10512 是一种 NF-κB 抑制剂。CAY10512 可抑制脑脊液和细胞外液中 NF-κB 敏感的促炎性 miRNA (miRNA-9、miRNA-125b、miRNA-146a、miRNA-155) 的上调。CAY10512 显著减少促炎性细胞因子 (例如 TNF-α、MCP-1、IL-8、IL-6) 的释放。CAY10512 可用于神经炎症、胰岛移植和 microRNA 调控的研究。

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CAY10512

CAY10512 Chemical Structure

CAS No. : 139141-12-1

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25 mg ￥2592
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CAY10512 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAY10512 is a NF-κB inhibitor. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid. CAY10512 significantly reduces the release of pro-inflammatory cytokines (such as TNF-α, MCP-1, IL-8, IL-6). CAY10512 can be used for researchs on neuroinflammation, islet transplantation and microRNA regulation[1][2][3].

IC50 & Target[1][2][3]

NF-κB

 

IL-6

 

IL-8

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
5.4 μM
Compound: 1; LD55
Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay
Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay
[PMID: 28126440]
体外研究
(In Vitro)

CAY10512 (5 μM, 0-96 h) 可有效抑制 AD-ECF 刺激的 HNG 细胞中 miRNA-9、miRNA-125b、miRNA146a 和 miRNA-155 的上调[1]。
CAY10512 (0.15 μM, 1-7 h) 通过抑制促炎因子的增加和组织因子 TF 的表达，显著保护胰岛活力，有效减轻胰岛细胞损伤[2]。
CAY10512 (0.25 μM, 25 h) 可显著抑制 MR 激动剂 (Aldosterone (HY-113313)、11-dehydrocorticosterone (HY-113447)) 在 BV-2 细胞中[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAY10512 相关抗体:

ELISA Assay[2]

Cell Line: Primary human islets
Concentration: 0.15 μM
Incubation Time: Pre-treat for one hour, then mix with autologous blood and incubate for another 1, 3, 6 h
Result: Prevented the increase of TNF-α, MCP-1, IL-8 and IL-6.

RT-PCR[3]

Cell Line: BV-2 cells
Concentration: 0.25 μM
Incubation Time: Pre-treatment for 1 hour, then add the stimulus and incubate for 24 hours
Result: Completely blocked the upregulation of IL-6 mRNA induced by Aldosterone and the upregulation of TNFR2 mRNA induced by 11-dehydrocorticosterone.

Western Blot Analysis[3]

Cell Line: BV-2 cells
Concentration: 0.25 μM
Incubation Time: Pre-treatment for 1 hour, then add the stimulus and incubate for 24 hours
Result: Completely blocked the phosphorylation of ILp65 induced by aldosterone and its translocation to the nucleus, as well as the upregulation of TNFR2 protein levels induced by 11-dehydrocorticosterone.
分子量

228.26

Formula

C15H13FO
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 97.0%

COA (282 KB)

产品使用指南 (1538 KB)
参考文献

CAY10512 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY10512139141-12-1CAY 10512CAY-10512NF-κBTNF ReceptorInterleukin RelatedNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRILAlzheimer's diseaseinflammatory signalingmicro RNAInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-120269
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