1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Cyasterone

Cyasterone 

目录号: HY-N0211
产品使用指南

Cyasterone,一种天然的 EGFR 抑制剂,主要分离自 Ajuga decumbens Thunb (Labiatae)。 Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可作为抗人类肿瘤的临床治疗性药物。

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Cyasterone Chemical Structure

Cyasterone Chemical Structure

CAS No. : 17086-76-9

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Description

Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a clinical therapeutic anti-tumor agent against human tumors[1].

In Vitro

Cyasterone (0-100μM; 24hours) inhibits cell growth in a concentration-and time-dependent manner, IC50 values are 38.50 mg/mL, 32.96 mg/mL in A549 and MGC823 cells ,respectively[1].

Cell Viability Assay[1]

Cell Line: A549, HCT116, MGC823 cells
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: Inhibited the growth of 3 human cancer lines A549, HCT116, MGC823 cells.
Molecular Weight

520.65

Formula

C₂₉H₄₄O₈

CAS No.

17086-76-9

SMILES

C[C@@]12[C@]([C@](C)([C@H](O)C[C@@H]3[C@@H](C)OC([C@H]3C)=O)O)([H])CC[C@@]1(O)C4=CC([C@]5([H])C[C@@H](O)[C@@H](O)C[C@]5(C)[C@@]4([H])CC2)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Cyasterone
目录号:
HY-N0211
需求量:

Cyasterone

Cat. No.: HY-N0211