1. Apoptosis
    Autophagy
    PI3K/Akt/mTOR
  2. Apoptosis
    Autophagy
    mTOR
    Akt
  3. Cyclovirobuxine D

Cyclovirobuxine D 

目录号: HY-N0107
产品使用指南

Cyclovirobuxine D (CVB-D) 是中药黄杨 Buxus microphylla 的主要活性成分。Cyclovirobuxine D 诱导自噬并减弱 AktmTOR 的磷酸化。Cyclovirobuxine D 通过抑制细胞周期进程和诱导线粒体介导的细胞凋亡 apoptosis 抑制癌细胞的增殖。Cyclovirobuxine D 治疗心肌梗死引起的心力衰竭,具有治疗心力衰竭的潜力。

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Cyclovirobuxine D Chemical Structure

Cyclovirobuxine D Chemical Structure

CAS No. : 860-79-7

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Description

Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis[2]. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction[3].

In Vitro

Cyclovirobuxine D (0-240 µM ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 µM[2].
Cyclovirobuxine D (0-120 µM; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner[2].
Cyclovirobuxine D (0-120 µM; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis. Cyclovirobuxine D (0-120 µM; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells[2].

Cell Viability Assay[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, 120 and 240 µM
Incubation Time: 24, 48, 72 hours
Result: Reduced Cell Viability and Colony Formation Ability of Gastric Cancer Cells

Cell Cycle Analysis[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 µM
Incubation Time: 48 hours
Result: Arrested cell cycle progressions of MGC-803 and MKN28 cells.

Apoptosis Analysis[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 µM
Incubation Time: 48 hours
Result: Induced apoptosis of MGC-803 and MKN28 cells.

Western Blot Analysis[2]

Cell Line: MGC-803 and MKN28 cells
Concentration: 0, 30, 60, and 120 µM
Incubation Time: 48 hours
Result: Up-regulated cleaved Caspase-3 and Bax and decreased the expression of Bcl-2 expression.
Molecular Weight

402.66

Formula

C₂₆H₄₆N₂O

CAS No.

860-79-7

SMILES

C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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× = ×
C1   V1   C2   V2

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产品名称:
Cyclovirobuxine D
目录号:
HY-N0107
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Cyclovirobuxine D

Cat. No.: HY-N0107