2. Gene
  3. HDAC6 - histone deacetylase 6 Gene

HDAC6 - histone deacetylase 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 6

种属: Rattus norvegicus

基因 ID: 108348065 | 基因类型: protein coding

关于 HDAC6

Primary_assembly X: 14,551,044-14,572,441 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 182 orthologues, 12 paralogues and is associated with 19 phenotypes.

功能概要

该基因编码的蛋白可启动脱乙酰酶活性。涉及多个过程，包括神经元的生成；调节蛋白质修饰过程；和对糖皮质激素的反应。位于轴突和中心体。用于研究多囊肾病和多囊肝病。高血压和多囊性肝病的生物标志物。该基因的人类直系同源物与软骨发育不良有关，伴有扁平椎、独特的短指畸形、脑积水和小眼畸形。与人类 HDAC6（组蛋白脱乙酰酶 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables deacetylase activity. Involved in several processes, including generation of neurons; regulation of protein modification process; and response to glucocorticoid. Located in axon and centrosome. Used to study polycystic kidney disease and polycystic liver disease. Biomarker of hypertension and polycystic liver disease. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2022]

HDAC6 基因产物(4)

mRNA Protein Name
XM_006256758.3 XP_006256820.1 histone deacetylase 6
XM_003752010.4 XP_003752058.1 histone deacetylase 6
XM_039100468.1 XP_038956396.1 histone deacetylase 6
XM_006256759.4 XP_006256821.1 histone deacetylase 6

HDAC6 蛋白结构

Arginase_HDAC

Arginase_HDAC: cl17011 (97 - 433)

HDAC6-dom2

HDAC6-dom2: cd10003 (483 - 833)

zf-UBP

zf-UBP: pfam02148 (1069 - 1131)

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  • 1152 a.a.
蛋白主名 其他名称

histone deacetylase 6

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-15149 Romidepsin Inhibitor 99.98% 否
HY-10225 Belinostat Inhibitor 99.95% 是
HY-13322 Pracinostat Inhibitor 99.82% 是
HY-B0494 Bufexamac Inhibitor ≥98.0% 否
Clinical Phase
生物活性分子 (15)
目录号 产品名 作用方式
纯度 Phase
HY-10990 Abexinostat Inhibitor 98.61% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842 Givinostat Inhibitor 98.05% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-138799 KA2507 Inhibitor 98.09% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-14718 Resminostat Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 99.19% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
Pre-clinical Phase
生物活性分子 (140)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13271A Tubastatin A Inhibitor 98.37% 否
HY-18361 TMP195 Inhibitor 99.57% 否
HY-N0931 Santacruzamate A Inhibitor 99.04% 否
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-18360 TMP269 Inhibitor 98.05% 否
HY-13428 Tubacin Inhibitor 95.50% 否
HY-15224 PCI-34051 Inhibitor 99.69% 否
HY-13271 Tubastatin A Hydrochloride Inhibitor 98.21% 否
HY-18613 CAY10603 Inhibitor ≥98.0% 否
HY-16699 Nexturastat A Inhibitor 99.03% 否
HY-111791 ACY-1083 Inhibitor 99.80% 否
HY-19327 ACY-738 Inhibitor 99.92% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-N0071 Crotonoside Inhibitor 99.64% 否
HY-126147 J22352 Inhibitor 98.72% 否
HY-111400 SR-4370 Inhibitor 99.95% 否
HY-19328 ACY-775 Inhibitor 99.83% 否
HY-153392 TYA-018 Inhibitor 98.71% 否
HY-100871 WT-161 Inhibitor 98.36% 否
HY-111818 TH34 Inhibitor 98.41% 否
HY-18976 UF010 99.84% 否
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% 否
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 98.21% 否
HY-19747 HPOB Inhibitor 99.80% 否
HY-12954 PTACH Inhibitor 99.65% 否
HY-13267 Droxinostat Inhibitor 98.91% 否
HY-18712 BG45 Inhibitor 99.96% 否
HY-116818 Crebinostat Inhibitor 99.79% 否
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% 否
HY-144779 HDAC10-IN-1 Inhibitor 99.11% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-123976 MPT0G211 Inhibitor 99.55% 否
HY-120448A QTX125 TFA Inhibitor 99.93% 否
HY-18700 BRD73954 Inhibitor ≥98.0% 否
HY-146153 HDAC-IN-40 Inhibitor 98.71% 否
HY-135890 CG347B Inhibitor 98.93% 否
HY-114483 AES-135 Inhibitor 98.21% 否
HY-152134 HDAC6 degrader-3 Degrader 98.60% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-138831 AES-350 Inhibitor 98.02% 否
HY-131708A FNDR-20123 Inhibitor 98.08% 否
HY-124053 BRD2492 Inhibitor 99.18% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-120448 QTX125 Inhibitor / 否
HY-161307 T-518 Inhibitor / 否
HY-131708 FNDR-20123 free base Inhibitor / 否
HY-151464 SHP2/HDAC-IN-1 Inhibitor / 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-161305 SE-7552 Inhibitor / 否
HY-128582 PI3K/HDAC-IN-1 Inhibitor / 否
HY-131970 LSD1/HDAC6-IN-1 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-123976A MPT0G211 mesylate Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-147991 PDE5/HDAC-IN-1 Inhibitor / 否
HY-162330 HDAC6-IN-36 Inhibitor / 否
HY-157314 HDAC6-IN-27 Inhibitor / 否
HY-149946 HDAC-IN-57 Inhibitor / 否
HY-144395 HDAC6-IN-4 Inhibitor / 否
HY-146539 HDAC-IN-35 Inhibitor / 否
HY-152146 HDAC-IN-50 Inhibitor / 否
HY-146159 PI3K/HDAC-IN-2 Inhibitor / 否
HY-149372 HDAC6-IN-17 Inhibitor / 否
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / 否
HY-144654 HDAC/Top-IN-1 Inhibitor / 否
HY-150503 KH-259 Inhibitor / 否
HY-151263 G4/HDAC-IN-1 Inhibitor / 否
HY-163369 HDAC6-IN-35 Inhibitor / 否
HY-150597 HDAC-IN-46 Inhibitor / 否
HY-143241 HDAC-IN-34 Inhibitor / 否
HY-144297 HDAC1-IN-3 Inhibitor / 否
HY-163207 sEH/HDAC6-IN-1 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-163368 HDAC6-IN-34 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-144782 HDAC10-IN-2 Inhibitor / 否
HY-130493 HPB Inhibitor / 否
HY-150586 PTG-0861 Inhibitor / 否
HY-152235 HDAC6-IN-15 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-149029 TH-6 Inhibitor 95.00% 否
HY-150577 HDAC-IN-45 Inhibitor / 否
HY-133147 HDAC3/6-IN-2 Inhibitor / 否
HY-115941 HDAC-IN-9 Inhibitor / 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% 否
HY-157385 HDAC-IN-67 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / 否
HY-144292 HDAC-IN-30 Inhibitor / 否
HY-126566 Trichostatin C Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-162378 LT-630 Inhibitor / 否
HY-161304 HDAC6-IN-33 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / 否
HY-145852 Top/HDAC-IN-2 Inhibitor / 否
HY-147731 HDAC6-IN-9 Inhibitor / 否
HY-163430 HDAC-IN-71 Inhibitor / 否
HY-161350 ALK/HDAC-IN-1 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-147892 HDAC-IN-42 Inhibitor / 否
HY-139181 NR160 Inhibitor / 否
HY-151153 HDAC1-IN-5 Inhibitor / 否
HY-161306 ITF5924 Inhibitor / 否
HY-156027 SIRT6-IN-3 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-141701 mTOR/HDAC-IN-1 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-162377 HDAC-IN-70 Inhibitor / 否
HY-157481 HDAC1-IN-6 Inhibitor / 否
HY-144332 PHD2/HDACs-IN-1 Inhibitor / 否
HY-151443 HDAC-IN-47 Inhibitor / 否
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / 否
HY-151896 HDAC6-IN-14 Inhibitor / 否
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / 否
HY-150694 HDAC6-IN-11 Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-163359 CYP17A1/HDAC6-IN-1 Inhibitor / 否
HY-144098 HDAC8-IN-2 Inhibitor / 否
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / 否
HY-149721 HDAC4-IN-1 Inhibitor / 否
HY-152133 PROTAC HDAC6 degrader 1 Degrader / 否
HY-146750 HDAC-IN-37 Inhibitor / 否
HY-151569 SAHA-OH Inhibitor / 否
HY-144725 HDAC1/6-IN-1 Inhibitor / 否
HY-151897 HDAC-IN-49 Inhibitor / 否
HY-163503 HDAC6-IN-38 Inhibitor / 否
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / 否
HY-158075 DNMT/HDAC-IN-1 Inhibitor / 否
HY-151261 HDAC6-IN-13 Inhibitor 98.08% 否
HY-161155 HDAC6-IN-31 Inhibitor / 否
HY-144449 mTOR/HDAC6-IN-1 Inhibitor / 否
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / 否
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens HDAC6 NCBI NCBI:10013
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