1. Gene
  2. HDAC6 - histone deacetylase 6 Gene

HDAC6 - histone deacetylase 6 Gene

中文名称:组蛋白脱乙酰酶 6

种属: Rattus norvegicus

基因 ID: 108348065 | 基因类型: protein coding

关于 HDAC6

Primary_assembly X: 14,551,044-14,572,441 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 182 orthologues, 12 paralogues and is associated with 19 phenotypes.

功能概要

该基因编码的蛋白可启动脱乙酰酶活性。涉及多个过程,包括神经元的生成;调节蛋白质修饰过程;和对糖皮质激素的反应。位于轴突和中心体。用于研究多囊肾病和多囊肝病。高血压和多囊性肝病的生物标志物。该基因的人类直系同源物与软骨发育不良有关,伴有扁平椎、独特的短指畸形、脑积水和小眼畸形。与人类 HDAC6(组蛋白脱乙酰酶 6)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables deacetylase activity. Involved in several processes, including generation of neurons; regulation of protein modification process; and response to glucocorticoid. Located in axon and centrosome. Used to study polycystic kidney disease and polycystic liver disease. Biomarker of hypertension and polycystic liver disease. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2022]

HDAC6 基因产物(4)

mRNA Protein Name
XM_006256758.3 XP_006256820.1 histone deacetylase 6
XM_003752010.4 XP_003752058.1 histone deacetylase 6
XM_039100468.1 XP_038956396.1 histone deacetylase 6
XM_006256759.4 XP_006256821.1 histone deacetylase 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deacetylase activity IDA
IDA: 通过直接分析推断
23868068 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19167333 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axonal transport of mitochondrion IMP
IMP: 通过突变表型推断
22937007 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: 通过表达模式推断
20097749 RGD
involved in negative regulation of axon extension involved in axon guidance IMP
IMP: 通过突变表型推断
19884510 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
19884510 RGD
involved in negative regulation of protein acetylation IMP
IMP: 通过突变表型推断
24464872 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
12850547 RGD
involved in positive regulation of cellular response to oxidative stress IMP
IMP: 通过突变表型推断
19884510 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: 通过突变表型推断
24434010 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
19167333 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
22331421 RGD
involved in positive regulation of tubulin deacetylation IMP
IMP: 通过突变表型推断
24464872 RGD
involved in regulation of microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
24464872 RGD
involved in regulation of mitochondrion organization IMP
IMP: 通过突变表型推断
22937007 RGD
involved in regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24464872 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
25452209 RGD
involved in response to corticosterone IMP
IMP: 通过突变表型推断
22331421 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
20538901 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
17316384 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
22937007 RGD
located in centrosome IDA
IDA: 通过直接分析推断
19167333 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HDAC6 蛋白结构

Arginase_HDAC

Arginase_HDAC: cl17011 (97 - 433)

HDAC6-dom2

HDAC6-dom2: cd10003 (483 - 833)

zf-UBP

zf-UBP: pfam02148 (1069 - 1131)

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  • 1152 a.a.
蛋白主名 其他名称

histone deacetylase 6

直系同源

种属 基因名 来源 基因 ID
Homo sapiens HDAC6 NCBI NCBI:10013