2. Gene
  3. HDAC6 - histone deacetylase 6 Gene

HDAC6 - histone deacetylase 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 6

种属: Rattus norvegicus

基因 ID: 108348065 | 基因类型: protein coding

关于 HDAC6

Primary_assembly X: 14,551,044-14,572,441 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 182 orthologues, 12 paralogues and is associated with 19 phenotypes.

功能概要

该基因编码的蛋白可启动脱乙酰酶活性。涉及多个过程，包括神经元的生成；调节蛋白质修饰过程；和对糖皮质激素的反应。位于轴突和中心体。用于研究多囊肾病和多囊肝病。高血压和多囊性肝病的生物标志物。该基因的人类直系同源物与软骨发育不良有关，伴有扁平椎、独特的短指畸形、脑积水和小眼畸形。与人类 HDAC6（组蛋白脱乙酰酶 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables deacetylase activity. Involved in several processes, including generation of neurons; regulation of protein modification process; and response to glucocorticoid. Located in axon and centrosome. Used to study polycystic kidney disease and polycystic liver disease. Biomarker of hypertension and polycystic liver disease. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2022]

HDAC6 基因产物(4)

mRNA Protein Name
XM_006256758.3 XP_006256820.1 histone deacetylase 6
XM_003752010.4 XP_003752058.1 histone deacetylase 6
XM_039100468.1 XP_038956396.1 histone deacetylase 6
XM_006256759.4 XP_006256821.1 histone deacetylase 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables deacetylase activity IDA
IDA: 通过直接分析推断
23868068 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19167333 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axonal transport of mitochondrion IMP
IMP: 通过突变表型推断
22937007 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: 通过表达模式推断
20097749 RGD
involved in negative regulation of axon extension involved in axon guidance IMP
IMP: 通过突变表型推断
19884510 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
19884510 RGD
involved in negative regulation of protein acetylation IMP
IMP: 通过突变表型推断
24464872 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
12850547 RGD
involved in positive regulation of cellular response to oxidative stress IMP
IMP: 通过突变表型推断
19884510 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: 通过突变表型推断
24434010 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
19167333 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
22331421 RGD
involved in positive regulation of tubulin deacetylation IMP
IMP: 通过突变表型推断
24464872 RGD
involved in regulation of microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
24464872 RGD
involved in regulation of mitochondrion organization IMP
IMP: 通过突变表型推断
22937007 RGD
involved in regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24464872 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
25452209 RGD
involved in response to corticosterone IMP
IMP: 通过突变表型推断
22331421 RGD
involved in response to dexamethasone IEP
IEP: 通过表达模式推断
20538901 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
17316384 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
22937007 RGD
located in centrosome IDA
IDA: 通过直接分析推断
19167333 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDAC6 蛋白结构

Arginase_HDAC

Arginase_HDAC: cl17011 (97 - 433)

HDAC6-dom2

HDAC6-dom2: cd10003 (483 - 833)

zf-UBP

zf-UBP: pfam02148 (1069 - 1131)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1152 a.a.
蛋白主名 其他名称

histone deacetylase 6

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-15149 Romidepsin Inhibitor 99.98% 否
HY-10225 Belinostat Inhibitor 99.95% 是
HY-14842 Givinostat Inhibitor 98.67% 是
HY-13322 Pracinostat Inhibitor 99.80% 是
HY-B0494 Bufexamac Inhibitor ≥98.0% 否
Clinical Phase
生物活性分子 (15)
目录号 产品名 作用方式
纯度 Phase
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 4
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 98.06% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-13432 Nanatinostat Inhibitor 99.34% Phase 2
HY-138799 KA2507 Inhibitor 99.24% Phase 2
HY-101780 Tinostamustine Inhibitor 99.64% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-13432A Nanatinostat TFA Inhibitor / Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 98.66% Phase 1
Pre-clinical Phase
生物活性分子 (211)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13271A Tubastatin A Inhibitor 99.07% 否
HY-18361 TMP195 Inhibitor 99.82% 否
HY-18998 LMK-235 Inhibitor 99.61% 否
HY-N0931 Santacruzamate A Inhibitor 99.54% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-15224 PCI-34051 Inhibitor 99.84% 否
HY-13271 Tubastatin A Hydrochloride Inhibitor 99.31% 否
HY-18360 TMP269 Inhibitor 98.16% 否
HY-18613 CAY10603 Inhibitor 99.76% 否
HY-19327 ACY-738 Inhibitor 99.92% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-111818 TH34 Inhibitor 99.52% 否
HY-153392 TYA-018 Inhibitor 99.84% 否
HY-119939 CHDI-390576 Inhibitor 98.10% 否
HY-N0071 Crotonoside Inhibitor 99.46% 否
HY-111791 ACY-1083 Inhibitor 99.80% 否
HY-19328 ACY-775 Inhibitor 99.71% 否
HY-115475 SW-100 Inhibitor 99.93% 否
HY-111400 SR-4370 Inhibitor 98.38% 否
HY-144779 HDAC10-IN-1 Inhibitor 99.11% 否
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% 否
HY-126147 J22352 Inhibitor 99.04% 否
HY-18976 UF010 99.83% 否
HY-161307 T-518 Inhibitor 98.40% 否
HY-161305 SE-7552 Inhibitor 99.48% 否
HY-126330 SS-208 Inhibitor 99.00% 否
HY-13267 Droxinostat Inhibitor 98.91% 否
HY-100871 WT-161 Inhibitor 98.36% 否
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 99.01% 否
HY-116818 Crebinostat Inhibitor 99.79% 否
HY-19747 HPOB Inhibitor 99.80% 否
HY-18712 BG45 Inhibitor 99.95% 否
HY-135890 CG347B Inhibitor 98.93% 否
HY-123976 MPT0G211 Inhibitor 99.79% 否
HY-124295 Imofinostat Inhibitor 99.40% 否
HY-171139 PROTAC HDAC6 degrader 2 Inhibitor 99.80% 否
HY-152134 HDAC6 degrader-3 Degrader 98.60% 否
HY-164099 LSD1/HDAC6-IN-2 Inhibitor 99.66% 否
HY-124053 BRD2492 Inhibitor 99.18% 否
HY-158075 DNMT/HDAC-IN-1 Inhibitor 99.87% 否
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% 否
HY-146153 HDAC-IN-40 Inhibitor 98.71% 否
HY-110280 MC1742 Inhibitor 99.20% 否
HY-12954 PTACH Inhibitor 99.65% 否
HY-18700 BRD73954 Inhibitor ≥98.0% 否
HY-114483 AES-135 Inhibitor 98.21% 否
HY-162616 SelSA Inhibitor 99.83% 否
HY-161304 HDAC6-IN-33 Inhibitor 98.96% 否
HY-124782 HDAC8-IN-8 Inhibitor 99.01% 否
HY-131708A FNDR-20123 Inhibitor 98.08% 否
HY-150109 Purinostat mesylate Inhibitor 99.45% 否
HY-138831 AES-350 Inhibitor 99.30% 否
HY-151261 HDAC6-IN-13 Inhibitor 98.08% 否
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.53% 否
HY-120448 QTX125 Inhibitor / 否
HY-130493 HPB Inhibitor 99.11% 否
HY-156027 SIRT6-IN-3 Inhibitor 98.19% 否
HY-174444 PROTAC HDAC degrader-2 Degrader / 否
HY-173266 TO-1187 Degrader / 否
HY-170495 HDAC6 degrader-5 Inhibitor / 否
HY-120448A QTX125 TFA Inhibitor 99.93% 否
HY-159109 HDAC6-IN-46 Inhibitor 98.51% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-135714 Bavarostat Inhibitor 99.51% 否
HY-172177 ROCK/HDAC-IN-2 Inhibitor / 否
HY-123976A MPT0G211 mesylate Inhibitor / 否
HY-131708 FNDR-20123 free base Inhibitor / 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-131970 LSD1/HDAC6-IN-1 Inhibitor / 否
HY-151464 SHP2/HDAC-IN-1 Inhibitor / 否
HY-128582 PI3K/HDAC-IN-1 Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-144725 HDAC1/6-IN-1 Inhibitor / 否
HY-174877 PROTAC HDAC6 degrader 6 Degrader / 否
HY-146750 HDAC-IN-37 Inhibitor / 否
HY-152235 HDAC6-IN-15 Inhibitor / 否
HY-158308 HDAC6-IN-41 Inhibitor / 否
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / 否
HY-174265 HDAC6-IN-60 Inhibitor / 否
HY-161524 HDAC6-IN-43 Inhibitor / 否
HY-157314 HDAC6-IN-27 Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-172873 HDSI-18 Inhibitor / 否
HY-146351 HDAC-IN-38 Inhibitor / 否
HY-162630 HDAC6-IN-44 Inhibitor / 否
HY-157481 HDAC1-IN-6 Inhibitor / 否
HY-176064 HDAC6-IN-58 Inhibitor / 否
HY-169156 HDAC6-IN-49 Inhibitor / 否
HY-151443 HDAC-IN-47 Inhibitor / 否
HY-162658 Leuxinostat Inhibitor / 否
HY-149372 HDAC6-IN-17 Inhibitor / 否
HY-169400 HDACs/EZH2-IN-1 Inhibitor / 否
HY-163894 HDAC6-IN-48 Inhibitor / 否
HY-176733 HDAC6-IN-61 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-157385 HDAC-IN-67 Inhibitor / 否
HY-152226 MC2590 Inhibitor 98.71% 否
HY-173330 HDAC-IN-89 Inhibitor / 否
HY-147991 PDE5/HDAC-IN-1 Inhibitor / 否
HY-150577 HDAC-IN-45 Inhibitor / 否
HY-173064 DS-103 Inhibitor / 否
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / 否
HY-144449 mTOR/HDAC6-IN-1 Inhibitor / 否
HY-150694 HDAC6-IN-11 Inhibitor / 否
HY-149721 HDAC4-IN-1 Inhibitor / 否
HY-147731 HDAC6-IN-9 Inhibitor / 否
HY-146159 PI3K/HDAC-IN-2 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-144782 HDAC10-IN-2 Inhibitor / 否
HY-163430 HDAC-IN-71 Inhibitor / 否
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / 否
HY-173555 HDAC6-IN-54 Inhibitor / 否
HY-169405 AAK1/HDACs-IN-1 Inhibitor / 否
HY-152146 HDAC-IN-50 Inhibitor / 否
HY-133147 HDAC3/6-IN-2 Inhibitor / 否
HY-163207 sEH/HDAC6-IN-1 Inhibitor / 否
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / 否
HY-144395 HDAC6-IN-4 Inhibitor / 否
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / 否
HY-162378 LT-630 Inhibitor / 否
HY-168650 ROCK/HDAC-IN-1 Inhibitor / 否
HY-151263 G4/HDAC-IN-1 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-149029 TH-6 Inhibitor 95.00% 否
HY-168962 HDAC-IN-88 Inhibitor / 否
HY-163503 HDAC6-IN-38 Inhibitor / 否
HY-172359 PROTAC HDAC6 degrader 4 Degrader / 否
HY-174396 PI3Kδ/HDAC6-IN-1 Inhibitor / 否
HY-163369 HDAC6-IN-35 Inhibitor / 否
HY-174149 HDAC6-IN-59 Inhibitor / 否
HY-147892 HDAC-IN-42 Inhibitor / 否
HY-159172 HDAC3-IN-4 Inhibitor / 否
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / 否
HY-139181 NR160 Inhibitor / 否
HY-169226 HDAC6-IN-51 Inhibitor / 否
HY-169938 LSD1/HDAC-IN-2 Inhibitor / 否
HY-173184 HDAC6-IN-53 Inhibitor / 否
HY-124946 C1A Inhibitor / 否
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / 否
HY-161783 HDAC6-IN-45 Inhibitor / 否
HY-161984 HDAC-IN-76 Inhibitor / 否
HY-150503 KH-259 Inhibitor / 否
HY-161778 ZG-126 Inhibitor / 否
HY-150597 HDAC-IN-46 Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-162910 HDAC-IN-79 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-161854 LASSBio-1911 Inhibitor / 否
HY-123971 HDAC6 degrader-4 Degrader / 否
HY-163834 HDAC6-IN-47 Inhibitor / 否
HY-170379 HDAC-IN-84 Inhibitor / 否
HY-126566 Trichostatin C Inhibitor / 否
HY-172129 HDAC6-IN-52 Inhibitor / 否
HY-162330 HDAC6-IN-36 Inhibitor / 否
HY-144098 HDAC8-IN-2 Inhibitor / 否
HY-161306 ITF5924 Inhibitor / 否
HY-146276 CDK/HDAC-IN-2 Inhibitor / 否
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / 否
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / 否
HY-162781 HDAC1/6-IN-2 Inhibitor / 否
HY-150586 PTG-0861 Inhibitor / 否
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / 否
HY-147934 HDAC8-IN-3 Inhibitor / 否
HY-141701 mTOR/HDAC-IN-1 Inhibitor / 否
HY-146539 HDAC-IN-35 Inhibitor / 否
HY-158371 HDAC/CK2-IN-1 Inhibitor / 否
HY-152133 PROTAC HDAC6 degrader 1 Degrader / 否
HY-115941 HDAC-IN-9 Inhibitor / 否
HY-147966 HDAC-IN-43 Inhibitor / 否
HY-161350 ALK/HDAC-IN-1 Inhibitor / 否
HY-163359 CYP17A1/HDAC6-IN-1 Inhibitor / 否
HY-162955 LSD1/HDAC-IN-1 Inhibitor / 否
HY-161667 GSK-3β/HDAC-IN-1 Inhibitor / 否
HY-174449 HDAC6-IN-62 Inhibitor / 否
HY-161516 HDAC6-IN-42 Inhibitor / 否
HY-159171 sEH/HDAC6-IN-2 Inhibitor / 否
HY-168477 HDAC1-IN-8 Inhibitor / 否
HY-151896 HDAC6-IN-14 Inhibitor / 否
HY-143877 NN-390 Inhibitor / 否
HY-161688 HDAC-IN-73 Inhibitor / 否
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% 否
HY-168508 PB200 Inhibitor / 否
HY-162678 HDAC-IN-75 Inhibitor / 否
HY-151153 HDAC1-IN-5 Inhibitor / 否
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否
HY-169157 HDAC6-IN-50 Inhibitor / 否
HY-144332 PHD2/HDACs-IN-1 Inhibitor / 否
HY-161155 HDAC6-IN-31 Inhibitor / 否
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / 否
HY-149946 HDAC-IN-57 Inhibitor / 否
HY-12487 NL-103 Inhibitor / 否
HY-169940 Fibrostat Inhibitor / 否
HY-172159 FF2039 Inhibitor / 否
HY-151897 HDAC-IN-49 Inhibitor / 否
HY-172200 PD-L1/HDAC6-IN-1 Inhibitor / 否
HY-163368 HDAC6-IN-34 Inhibitor / 否
HY-143241 HDAC-IN-34 Inhibitor / 否
HY-144297 HDAC1-IN-3 Inhibitor / 否
HY-144292 HDAC-IN-30 Inhibitor / 否
HY-145852 Top/HDAC-IN-2 Inhibitor / 否
HY-144654 HDAC/Top-IN-1 Inhibitor / 否
HY-151569 SAHA-OH Inhibitor / 否
HY-139815 ZYJ-34c Inhibitor / 否
HY-160846 HDAC6-IN-40 Inhibitor / 否
HY-160845 HDAC6-IN-39 Inhibitor / 否
HY-148624 CHDI-00484077 Inhibitor / 否
HY-119316A CM-545 Inhibitor / 否
HY-139795 ZYJ-25e Inhibitor / 否
HY-19754 CRA-026440 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens HDAC6 NCBI NCBI:10013
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