1. Cell Cycle/DNA Damage
    Epigenetics
    PI3K/Akt/mTOR
    Apoptosis
  2. HDAC
    Akt
    Apoptosis
  3. MPT0E028

MPT0E028 

目录号: HY-124295
产品使用指南

MPT0E028 是一种口服有效的,选择性 HDAC 抑制剂,对 HDAC1,HDAC2 和 HDAC6 的 IC50 分别为 53.0 nM,106.2 nM,29.5 nM。MPT0E028 通过诱导细胞凋亡降低 B 细胞淋巴瘤的活力,同时具有有效的直接 Akt 靶向能力,降低 B 细胞淋巴瘤中的 Akt 磷酸化。MPT0E028 具有良好的抗癌能力。

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MPT0E028 Chemical Structure

MPT0E028 Chemical Structure

CAS No. : 1338320-94-7

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Description

MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively[1]. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity[2].

IC50 & Target[1,2]

HDAC1

53.0 nM (IC50)

HDAC2

106.2 nM (IC50)

HDAC6

29.5 nM (IC50)

HDAC8

2532.6 nM (IC50)

Akt

 

Molecular Weight

344.38

Formula

C₁₇H₁₆N₂O₄S

CAS No.

1338320-94-7

SMILES

O=C(/C=C/C1=CC2=C(C=C1)N(CC2)S(=O)(C3=CC=CC=C3)=O)NO

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
MPT0E028
目录号:
HY-124295
需求量:

MPT0E028

Cat. No.: HY-124295