1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. JNJ-55511118

JNJ-55511118 是一种高效的可逆的选择性 AMPA 受体调节剂,对 TARP-γ8 有选择性。 JNJ-55511118 在竞争结合实验中可完全置换放射性配体,Ki 为 26 nM。 JNJ-55511118 是一种工具分子,可用作抗惊厥剂或神经保护剂。

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JNJ-55511118 Chemical Structure

JNJ-55511118 Chemical Structure

CAS No. : 2036081-86-2

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生物活性

JNJ-55511118 is a highly potent, reversible, and selective AMPA receptor inhibitor selective for TARP-γ8. JNJ-55511118 fully displaces the radioligand (20 nM) with the Ki of 26 nM in competition binding experiments. JNJ-55511118 is a tool molecule with potential therapeutic utility as an anticonvulsant or neuroprotectant[1].

分子量

328.67

Formula

C14H8ClF3N2O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
JNJ-55511118
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HY-118424
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