2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. MEK VEGFR FLT3 PDGFR
  4. L-783277

L-783277 (Compound 4) 是一种 MEK 抑制剂 (IC50 = 4 nM)。L-783277 对多种激酶具有强效抑制活性，包括 VEGFR2/3、FLT1/3/4、MEK1/2、KDR 和 PDGFRα，但对激酶的选择性较低。L-783277 可抑制 H295R 细胞的活力 (IC50 = 22 mM) 和细胞增殖 (IC50 = 21 mM)。L-783277 可用于肾上腺皮质癌等癌症的研究。

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L-783277

L-783277 Chemical Structure

CAS No. : 791807-02-8

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L-783277 相关抗体

Top Publications Citing Use of Products

查看 MEK 亚型特异性产品:

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM). L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma[1][2].

分子量

364.39

Formula

C19H24O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L-783277 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-783277791807-02-8L783277L 783277MEKVEGFRFLT3PDGFRMitogen-activated protein kinase kinaseMAPKKMAP2KVascular endothelial growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Platelet-derived growth factor receptorMEK inhibitorH295R cellsadrenocortical carcinomaInhibitorinhibitorinhibit

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