2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. Estrogen Receptor/ERR Apoptosis
  4. MPP dihydrochloride

MPP dihydrochloride 

目录号: HY-103454 纯度: 99.03%
COA 产品使用指南

摩尔计算器

MPP dihydrochloride 是一种强效的选择性 ER (雌激素受体)调节剂。MPP dihydrochloride 可诱导子宫内膜癌和 oLE 细胞凋亡。MPP dihydrochloride 可逆转 β - 雌激素的积极作用。在体内，MPP dihydrochloride 对小鼠子宫 ERalpha 具有激动剂和拮抗剂的混合作用。

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MPP dihydrochloride Chemical Structure

MPP dihydrochloride Chemical Structure

CAS No. : 911295-24-4

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规格 价格 是否有货 数量
5 mg ￥1600
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10 mg ￥2400
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25 mg ￥5000
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50 mg ￥8000
In-stock
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200 mg   询价  

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Customer Review

Other Forms of MPP dihydrochloride:

MPP dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3].

IC50 & Target

ERα

 

ERβ

 

体外研究
(In Vitro)

MPP dihydrochloride (1、5、10、25、50 和 100 μM；24 小时) 在 RL95-2 细胞中降低细胞活力，IC50 值为 20.01 μM[1]。
MPP dihydrochloride 在浓度为 10 μM 时在 RL95-2 细胞中表现出抗增殖活性[1]。
MPP dihydrochloride (20 μM；24 h) 降低磷酸化ERα，但它不会改变 Akt 的磷酸化。MPP dihydrochloride 降低 p-ERα/ERα 的比率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MPP dihydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: RL95-2 endometrium cancer cells
Concentration: 1, 5, 10, 25, 50 and 100 µM
Incubation Time: 24 hours
Result: The treatment with 25 µM, 50 µM and 100 µM for 24 h decreased cell viability significantly. However, cell viability was not significantly changed by MPP dihydrochloride at concentration below 25 µM.

Cell Proliferation Assay[1]

Cell Line: RL95-2 cell
Concentration: 10, 15, 20 and 25 µM
Incubation Time: 72 hours
Result: Showed antiproliferative activity at a concentration of 10 μM.

Western Blot Analysis[1]

Cell Line: RL95-2 cell line
Concentration: 20 µM
Incubation Time: 24 hours
Result: Reduced the phosphorylation of ERα, while it did not alter the phosphorylation of Akt. Reduced the ratio of p-ERα/ERα compared to the control group.
体内研究
(In Vivo)

MPP dihydrochloride (20 μg/kg 或 200 μg/kg ) 导致前脉冲抑制百分比 (PPI) 呈剂量依赖性衰减[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6N mice at the age of 9-10 weeks[2]
Dosage: Low dose (20 μg/kg body weight) or high dose (200 μg/kg body weight)
Administration: Administered subcutaneously (s.c.) injected; injection volume of 5 mL/kg; 60 min before PPI testing
Result: Led to a dose-dependent attenuation of percent PPI. Pretreatment with 200 μg/kg reduced the mean percent PPI scores by ~30%.
分子量

542.50

Formula

C29H33Cl2N3O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 30 mg/mL (55.30 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8433 mL 9.2166 mL 18.4332 mL
5 mM 0.3687 mL 1.8433 mL 3.6866 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.06%

COA (264 KB) LCMS (256 KB)

产品使用指南 (1538 KB)
参考文献

MPP dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8433 mL 9.2166 mL 18.4332 mL 46.0829 mL
5 mM 0.3687 mL 1.8433 mL 3.6866 mL 9.2166 mL
10 mM 0.1843 mL 0.9217 mL 1.8433 mL 4.6083 mL
15 mM 0.1229 mL 0.6144 mL 1.2289 mL 3.0722 mL
20 mM 0.0922 mL 0.4608 mL 0.9217 mL 2.3041 mL
25 mM 0.0737 mL 0.3687 mL 0.7373 mL 1.8433 mL
30 mM 0.0614 mL 0.3072 mL 0.6144 mL 1.5361 mL
40 mM 0.0461 mL 0.2304 mL 0.4608 mL 1.1521 mL
50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.9217 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPP911295-24-4Estrogen Receptor/ERRApoptosisAktERαRL95-2endometriumcancerInhibitorinhibitorinhibit

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MPP dihydrochloride
目录号：
HY-103454
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