2. 诱导疾病模型产品 Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein Autophagy
  3. 心血管系统疾病模型 Endogenous Metabolite Adrenergic Receptor Autophagy
  4. 心脏疾病模型
  5. Norepinephrine tartrate

Norepinephrine tartrate  (Synonyms: 去甲肾上腺素酒石酸盐; Levarterenol tartrate; L-Noradrenaline tartrate)

目录号: HY-13715C
产品使用指南

摩尔计算器

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate 是一种有效的肾上腺素能受体 (AR) 激动剂。Norepinephrine tartrate 可以激活 α1、α2、β1 受体。

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Norepinephrine tartrate Chemical Structure

Norepinephrine tartrate Chemical Structure

CAS No. : 51-40-1

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Other Forms of Norepinephrine tartrate:

Norepinephrine tartrate 相关抗体

Top Publications Citing Use of Products

    Norepinephrine tartrate purchased from MCE. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311.  [Abstract]

    Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

    Norepinephrine tartrate purchased from MCE. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.  [Abstract]

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.

    查看 Adrenergic Receptor 亚型特异性产品:

    查看所有亚型
    α adrenergic receptor β adrenergic receptor

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α1, α2, β1 receptors[1][2][3][4].

    IC50 & Target[1]

    α1-adrenergic receptor

     

    α2-adrenergic receptor

     

    Beta-1 adrenergic receptor

     

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体外研究
    (In Vitro)

    Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations[2].
    Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
    Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
    Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Norepinephrine tartrate 相关抗体:

    RT-PCR[2]

    Cell Line: Subcutaneous preadipocytes Adipocytes.
    Concentration: 10 μM.
    Incubation Time: 6 hours.
    Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA)
    体内研究
    (In Vivo)

    诱导心肌病[5][6]
    致病原理
    Norepinephrine 是心肌细胞的一种强效生长因子，通过在动物体内长期输注亚高压剂量的Norepinephrine 可引起心肌质量和左心室壁厚度的增加。Norepinephrine 通过 α1 和 β肾上腺素能刺激激活 raf-1 激酶/MAP 激酶级联，来自两个受体的信号通路协同诱导心肌细胞肥大。
    具体造模方法
    Rat: Spragues-Dawley rats • adult (6 months old) • Male &bull.
    Administration: Each rat was continuously injected with 100 μg/kg/h (Norepinephrine; HY-13715) or 200 μg/kg/h (Norepinephrine; HY-13715) through an osmotic minipump.
    造模成功指标
    分子变化：显著增加左心室 Dnmt活性和Dnmt1、3a 和 3b 的表达。
    显著增加左心室中胎儿基因 ANP、BNP 和 βMHC 的 mRNA 表达。
    显著增加左心室 ROS 生成并以浓度依赖方式增加整体基因组 DNA 甲基化和左心室 PKCε 启动子区域 Egr-1 结合位点基因特异性 CpG 甲基化。
    以浓度依赖性方式增加乳酸脱氢酶释放。
    显著降低左心室发育压力和 dP/dtmax、诱导了肌营养蛋白的上调和四加半LIM域蛋白2 (FHL2) 的下调。
    表型观测：增加心肌梗死面积并持续升高血压。
    诱导心脏肥厚和心脏收缩力降低。
    增加左心室体重。
    拮抗产品 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    319.26

    Formula

    C12H17NO9
    CAS 号
    中文名称

    去甲肾上腺素酒石酸盐
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Norepinephrine tartrate 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Norepinephrine51-40-1LevarterenolL-Noradrenaline去甲肾上腺素酒石酸盐Endogenous MetaboliteAdrenergic ReceptorAutophagyBeta Receptoradrenergic receptorα1α2β1Inhibitorinhibitorinhibit

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