2. Protein Tyrosine Kinase/RTK Apoptosis Cell Cycle/DNA Damage
  3. Src Bcr-Abl Apoptosis Wee1
  4. PD173952

PD173952 是一种酪氨酸激酶抑制剂，对 Lyn、Abl 和 Csk 的 IC50 分别为 0.3、1.7 和 6.6 nM。PD173952 也是 Myt1 抑制剂，Ki 为 8.1 nM。PD173952 诱导凋亡 (apoptosis)。

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PD173952 Chemical Structure

PD173952 Chemical Structure

CAS No. : 305820-75-1

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规格 价格 是否有货 数量
5 mg ￥2808
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PD173952 相关抗体

Top Publications Citing Use of Products

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Lck

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2].

IC50 & Target[1][2]

Lyn

0.3 nM (IC50)

Abl

1.7 nM (IC50)

Csk

6.6 nM (IC50)

Myt1

8.1 nM (Ki)

体外研究
(In Vitro)

PD173952 (0-1000 nM; 12 h) 以浓度依赖方式抑制 K562 细胞中 p210Bcr-Abl 和 CrkL 的酪氨酸磷酸化[1]。
PD173952 (0.5 μM; 1-4 days) 抑制 K562 细胞活力[1]。
PD173952 (0.5 μM; 24 and 48 h) 诱导 K562 和 MEG-01 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD173952 相关抗体:

Western Blot Analysis[1]

Cell Line: K562 cells
Concentration: 0, 25, 50, 100, 200, 500 and 1000 nM
Incubation Time: 12 h
Result: Inhibited tyrosine phosphorylation of p210Bcr-Abl and CrkL.

Cell Viability Assay[1]

Cell Line: K562 cells
Concentration: 0.5 μM
Incubation Time: 1-4 days
Result: Caused cell death in a time-dependent manner.

Western Blot Analysis[1]

Cell Line: K562 and MEG-01 cells
Concentration: 0.5 μM
Incubation Time: 24 and 48 h
Result: 85-kDa PARP fragment was detected.
分子量

482.36

Formula

C24H21Cl2N5O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

PD173952 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD173952305820-75-1PD 173952PD-173952SrcBcr-AblApoptosisWee1LynAblCskMyt1K562MEG-01Inhibitorinhibitorinhibit

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目录号：
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