2. PROTAC Apoptosis
  3. PROTACs Bcl-2 Family
  4. PZ703b TFA

PZ703b TFA 是一种 Bcl-xl PROTAC 降解剂，可以诱导细胞凋亡 ( apoptosis)，抑制癌细胞增殖，用于膀胱癌研究。

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PZ703b TFA Chemical Structure

PZ703b TFA Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥9800
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Other Forms of PZ703b TFA:

PZ703b TFA 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research[1][2].

IC50 & Target

Bcl-xL

 

体外研究
(In Vitro)

PZ703b (0-1 μM, 24 h) TFA can synergistically inhibit bladder cancer cell proliferation with Mivebresib in a dose-dependent manner and induce apoptosis in bladder cancer cells via the mitochondrial pathway[1].
PZ703b (0-1 μM, 48 h) TFA inhibits MOLT-4 and RS4;11 cells with the IC50 values of 15.9 and 11.3 nM respectively[2].
PZ703b (10 nM, 48 h)TFA induces rapid and durable BCL-XL degradation and apoptosis in MOLT-4 cells through the caspase-3 mediated pathway[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PZ703b TFA 相关抗体:

Apoptosis Analysis[1]

Cell Line: Bladder cancer cell lines 5637, SW780, and HT-1977
Concentration: 1 μM
Incubation Time: 24 hours
Result: Induction of Bcl-xl degradation increased the association between Mcl-1 and Bim (a pro-apoptotic Bcl-2 protein). It was further shown that forced expression of Bcl-xl or Mcl-1 significantly reduced PZ703b-induced apoptosis.
Resulted in a slight activation of Bax and Bak.
分子量

1714.46

Formula

C82H103ClF6N10O13S4
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

PZ703b TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ703bPROTACsBcl-2 FamilyBcl-xlPROTACapoptosiscancerbladder cancerInhibitorinhibitorinhibit

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产品名称：
PZ703b TFA
目录号：
HY-115718A
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