1. Immunology/Inflammation
  2. COX
  3. SC-58125

SC-58125 是一种有效的和选择性的环氧合酶 2 (COX-2) 的抑制剂,IC50 值为 0.04 μM。SC-58125 在体外和体内均表现出抗肿瘤活性,还可以抑制炎症部位的水肿并具有缓解疼痛作用。

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SC-58125 Chemical Structure

SC-58125 Chemical Structure

CAS No. : 162054-19-5

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5 mg ¥700
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10 mg ¥1200
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100 mg ¥6800
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查看 COX 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect[1][2][3].

IC50 & Target

hCOX-2

0.04 μM (IC50)

hCOX-1

>100 μM (IC50)

体外研究
(In Vitro)

SC-58125 (0.001-100 μM) has a high degree of selectivity for the inducible form of COX-2 (IC50=1 μM) over the COX-1 (IC50>100 μM)[1].
SC-58125 (10 μM; 20-140 s) is time-dependent and is complete by 1 min, with a half-maximal inhibition at 20 s[1].
SC-58125 (25-100 μM; 3 d) inhibits the in vitro growth of HCA-7 and LLC cells[3].
SC-58125 (100 µM; 12 h) induces G2 arrest in LLC cells[3].
SC-58125 (25-100 μM; 3 d) decreases p34cdc2 levels in HCA-7 cells[3].
SC-58125 (100 µM; 24 or 72 h) does not induce apoptosis of HCA-7 and LLC cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: HCA-7 and LLC cells
Concentration: 0, 25, 50, 100 μM
Incubation Time: 3 days
Result: Reduced the cell number and MTT activity in both cell lines in a dose-dependent manner.

Cell Cycle Analysis[3]

Cell Line: LLC cells
Concentration: 100 μM
Incubation Time: 12 hours
Result: Increased in the number of cells containing 4n DNA content in a dose- and time-dependent manner.
Reduced the number of mitotic figures.

Western Blot Analysis[3]

Cell Line: HCA-7 cells
Concentration: 0, 25, 50, 100 μM
Incubation Time: 3 days
Result: Resulted in a dose-dependent decrease in p34cdc2 activity with strong inhibition, even at the lowest concentration.
体内研究
(In Vivo)

SC-58125 (10 mg/kg; i.p. every 48 h) inhibits the growth of established colorectal cancer xenografts in mice[3].
SC-58125 (10 mg/kg; a single i.p.) reduces tumor PGE2 levels in mice[3].
SC-58125 (10 mg/kg; a single i.p.) does not change the tumor levels of COX-1 and COX-2 protein in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic Sprague-Dawley mice are injected HCA-7 cells[3]
Dosage: 10 mg/kg
Administration: I.p. every 48 h; at the time of tumor implantation or 2 and 4 weeks later
Result: Decreased the tumor growth rates significantly.
分子量

384.35

Formula

C17H12F4N2O2S

CAS 号
性状

固体

颜色

Off-white to pink

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (650.45 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6018 mL 13.0090 mL 26.0180 mL
5 mM 0.5204 mL 2.6018 mL 5.2036 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SC-58125 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6018 mL 13.0090 mL 26.0180 mL 65.0449 mL
5 mM 0.5204 mL 2.6018 mL 5.2036 mL 13.0090 mL
10 mM 0.2602 mL 1.3009 mL 2.6018 mL 6.5045 mL
15 mM 0.1735 mL 0.8673 mL 1.7345 mL 4.3363 mL
20 mM 0.1301 mL 0.6504 mL 1.3009 mL 3.2522 mL
25 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.6018 mL
30 mM 0.0867 mL 0.4336 mL 0.8673 mL 2.1682 mL
40 mM 0.0650 mL 0.3252 mL 0.6504 mL 1.6261 mL
50 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3009 mL
60 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0841 mL
80 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8131 mL
100 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6504 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SC-58125
目录号:
HY-W013164
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