1. Protein Tyrosine Kinase/RTK
  2. SHP2
  3. SHP099 hydrochloride

SHP099 hydrochloride 是一种变构 SHP2 抑制剂,对 SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K 的 IC50s 为0.690, 1.241, 0.416, 1.968, 2.896 μM。SHP099 hydrochloride 抑制癌细胞生长,例如 MV4-11 和 TF-1 细胞 (IC50: 0.32 和 1.73 μM)。SHP099 hydrochloride 抑制 RAS-ERK 信号传导并抑制肿瘤生长。

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SHP099 hydrochloride Chemical Structure

SHP099 hydrochloride Chemical Structure

CAS No. : 1801747-11-4

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SHP099 hydrochloride 的其他形式现货产品:

Other Forms of SHP099 hydrochloride:

MCE 顾客使用本产品发表的 53 篇科研文献

WB

    SHP099 hydrochloride purchased from MCE. Usage Cited in: Cancer Discov. 2018 Oct;8(10):1237-1249.  [Abstract]

    Immunoblots of whole cell lysates or GST-RBD-precipitated (RAS-GTP, KRASGTP and NRAS-GTP) lysates from PDAC cells treated with DMSO, SHP099 10 μM, AZD6244 1 μM, or both drugs for the times indicated.

    SHP099 hydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2019 Apr 1;10(1):1473.  [Abstract]

    SHP099 inhibits IRS1-AP2 interaction in primary hepatocytes.

    SHP099 hydrochloride purchased from MCE. Usage Cited in: Hepatology. 2018 Jul;68(1):333-348.  [Abstract]

    Primary human HSCs are treated with SHP099 for 1 hour. PDGF-BB is added and cells are cultured for 12 additional hours. Whole cell lysates and EVs are examined by WB (n=6).

    SHP099 hydrochloride purchased from MCE. Usage Cited in: Open Biol. 2017 May;7(5). pii: 170066.  [Abstract]

    Comparing the effects of SHP2 degradation and allosteric inhibition on Ras/MAPK signalling. (a) Human U2OS, A549, K-562 and MDA-MB-468 cells are treated with DMSO control or 1, 5 and 10 µM SHP099 for 2 h prior to lysis. Extracts (10 µg protein) are resolved by SDS-PAGE and transferred to nitrocellulose membranes, which are subjected to western blotting with the indicated antibodies. (b) Uninfected U2OS cells (WT) or cells infected with retroviruses encoding VHL, aCS3 and VHL-aCS3 are treated wit
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    SHP099 hydrochloride is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 hydrochloride inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM). SHP099 hydrochloride inhibits RAS-ERK signaling and inhibit tumor growth[1][2].

    IC50 & Target

    0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K[1]

    Formula

    C16H19Cl2N5.xClH

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献

    SHP099 hydrochloride 相关分类

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    SHP099 hydrochloride
    目录号:
    HY-100388B
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