2. GPCR/G Protein
  3. GLP Receptor
  4. Tirzepatide hydrochloride

Tirzepatide hydrochloride  (Synonyms: LY3298176 hydrochloride)

目录号: HY-P1731B 纯度: 99.82%
COA 产品使用指南

摩尔计算器

Tirzepatide hydrochloride (LY3298176 hydrochloride) 是葡萄糖依赖性胰岛素营养多肽 (GIP) 和胰高血糖素样肽-1 (GLP-1) 受体双重激动剂。Tirzepatide hydrochloride 具有神经保护作用，可以用于2 型糖尿病、糖尿病相关的神经病变和肥胖症的研究。

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Tirzepatide hydrochloride Chemical Structure

Tirzepatide hydrochloride Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2400
In-stock
5 mg ￥5200
In-stock
10 mg ￥8400
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Tirzepatide hydrochloride:

Tirzepatide hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tirzepatide hydrochloride (LY3298176 hydrochloride) is a glucose-dependent insulin nutritive polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist. Tirzepatide hydrochloride has neuroprotective effects and can be used in the study of type 2 diabetes, diabetes-related neuropathy and obesity[1][2][3].

体外研究
(In Vitro)

Tirzepatide hydrochloride (0-0.4 μM, 7 天) 可以改善高糖诱导的 SHSY5Y 人神经母细胞瘤细胞的神经变性和克服神经元胰岛素抵抗[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tirzepatide hydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: SHSY5Y
Concentration: 0-0.4 μM
Incubation Time: 7 days
Result: Upregulated the mRNA expression and protein levels of both CREB and BDNF.
Increased the Bcl-2 and decreased BAX protein levels.
Increased the pAkt, MAP2, GAP43, and AGBL4 protein levels.
Increased GLUT4 and SORBS1 protein levels.
体内研究
(In Vivo)

Tirzepatide hydrochloride (10 nmol/kg, 皮下注射) 可抑制饮食性肥胖小鼠结肠癌肿瘤生长[2]。
Tirzepatide hydrochloride (1.35 mg/kg, 腹腔注射, 每周一次) 通过调节糖尿病大鼠异常胰岛素抵抗和炎症反应改善空间学习记忆障碍[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) mice [2]
Dosage: 10 nmol/kg
Administration: s.c.
Result: Reduced body weight and food consumption.
Reduced glucose, insulin, leptin, and c-peptide levels.
Animal Model: MC38 colon cancer mice model[2]
Dosage: 10 nM/kg
Administration: s.c.
Result: Reduced tumor volumes.
Clinical Trial
分子量

4813.45 (free base)

Formula

C225H348N48O68.xHCl
性状

固体

颜色

White to off-white

Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{C20 diacid-gamma-Glu-(AEEA)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Sequence Shortening

Y-{Aib}-EGTFTSDYSI-{Aib}-LDKIAQ-{C20 diacid-gamma-Glu-(AEEA)2-Lys}-AFVQWLIAGGPSSGAPPPS-NH2
中文名称

盐酸替尔泊肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.82%

COA (165 KB) LCMS (89 KB) 元素分析报告 (202 KB)

产品使用指南 (1538 KB)
参考文献

Tirzepatide hydrochloride 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TirzepatideLY3298176盐酸替尔泊肽LY 3298176LY-3298176GLP ReceptorType 2 diabetesneuropathyAlzheimer's diseaseobesityInhibitorinhibitorinhibit

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目录号：
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