2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Topoisomerase HDAC Apoptosis
  4. Topo II/HDAC-IN-1

Topo II/HDAC-IN-1 (7d) 对 Topo II 和HDAC 表现出良好的双抑制活性。Topo II/HDAC-IN-1 (7d) 可诱导凋亡。

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Topo II/HDAC-IN-1

Topo II/HDAC-IN-1 Chemical Structure

CAS No. : 2922269-18-7

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Topo II/HDAC-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-1 (8d) induces apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
1143 μM
Compound: 7d
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 36996717]
MGC-803 IC50
9.59 μM
Compound: 7d
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 36996717]
U-937 IC50
28.46 μM
Compound: 7d
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay
[PMID: 36996717]
体外研究
(In Vitro)

Topo II/HDAC-IN-1 (7d) has the best inhibitory activity against MGC-803 and MCF-7, with IC50 values of 9.59 μM and 13.43 μM respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topo II/HDAC-IN-1 相关抗体:
分子量

332.38

Formula

C15H16N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topo II/HDAC-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topo II/HDAC-IN-12922269-18-7TopoisomeraseHDACApoptosisHistone deacetylasesTopo IIapoptosisInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-149238
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