1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Toremifene

Toremifene  (Synonyms: Z-Toremifene; NK 622 free base; FC-1157a free base)

目录号: HY-B0005A 纯度: 99.86%
COA 产品使用指南

Toremifene (Z-Toremifene) 是第二代选择性雌激素受体调节剂,对雌激素受体的 IC50 为 1μM。Toremifene 还可以有效抑制传染性 EBOV ZaireMarburg (MARV)IC50 分别为 0.07 µM 和 2.6 µM。

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Toremifene Chemical Structure

Toremifene Chemical Structure

CAS No. : 89778-26-7

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规格 价格 是否有货 数量
10 mg ¥400
In-stock
25 mg ¥720
In-stock
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100 mg   询价  

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Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

体外研究
(In Vitro)

Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis and other adverse effects resulting from ADT with prostate cancer[1].
The growth of Ac-1 cells was inhibited by tamoxifen, toremifene and atamestane in vitro with IC50values of 1.8±1.3μM, 1±0.3μM and 60.4±17.2μM, respectively. The combination of toremifene plusatamestane was found to be better than toremifene or atamestane alone in vitro[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

The effect of this combination was then studied in vivo using Ac-1 xenografts grown in ovariectomized female SCID mice. The mice were injected with toremifene (1000μg/day), atamestane (1000μg/day), tamoxifen (100μg/day), or the combination of toremifene plus atamestane. In this study, our results indicate that the combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

405.96

Formula

C26H28ClNO

CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

托瑞米芬;涛瑞米芬

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 62.5 mg/mL (153.96 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4633 mL 12.3165 mL 24.6330 mL
5 mM 0.4927 mL 2.4633 mL 4.9266 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4633 mL 12.3165 mL 24.6330 mL 61.5824 mL
5 mM 0.4927 mL 2.4633 mL 4.9266 mL 12.3165 mL
10 mM 0.2463 mL 1.2316 mL 2.4633 mL 6.1582 mL
15 mM 0.1642 mL 0.8211 mL 1.6422 mL 4.1055 mL
20 mM 0.1232 mL 0.6158 mL 1.2316 mL 3.0791 mL
25 mM 0.0985 mL 0.4927 mL 0.9853 mL 2.4633 mL
30 mM 0.0821 mL 0.4105 mL 0.8211 mL 2.0527 mL
40 mM 0.0616 mL 0.3079 mL 0.6158 mL 1.5396 mL
50 mM 0.0493 mL 0.2463 mL 0.4927 mL 1.2316 mL
60 mM 0.0411 mL 0.2053 mL 0.4105 mL 1.0264 mL
80 mM 0.0308 mL 0.1540 mL 0.3079 mL 0.7698 mL
100 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Toremifene
目录号:
HY-B0005A
需求量: