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  3. TRAF-STOP inhibitor 6877002

TRAF-STOP inhibitor 6877002 

目录号: HY-110247
产品使用指南

TRAF-STOP inhibitor 6877002,一种抑制 CD40-TRAF6 相互作用的选择性抑制剂,从专利 WO2014033122A1 中获得,抑制 RAW 细胞中 NF-κB 活化,化合物VII。TRAF-STOP 6877002 可阻止小鼠中已发生的动脉粥样硬化恶化,减少白细胞募集并减少巨噬细胞活化;减少动脉粥样硬化斑块中的巨噬细胞增殖。

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TRAF-STOP inhibitor 6877002 Chemical Structure

TRAF-STOP inhibitor 6877002 Chemical Structure

CAS No. : 433249-94-6

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Description

TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].

IC50 & Target

CD40-TRAF6 interaction; NF-κB

Molecular Weight

251.32

Formula

C₁₇H₁₇NO

CAS No.

433249-94-6

SMILES

O=C(C1=CC=CC=C1)/C=C/NC2=C(C=CC(C)=C2)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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× = ×
C1   V1   C2   V2

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产品名称:
TRAF-STOP inhibitor 6877002
目录号:
HY-110247
需求量:

TRAF-STOP inhibitor 6877002

Cat. No.: HY-110247