2. Neuronal Signaling Stem Cell/Wnt Metabolic Enzyme/Protease Apoptosis
  3. γ-secretase Proteasome Apoptosis
  4. Z-LLNle-CHO

Z-LLNle-CHO  (Synonyms: Z-Leu-Leu-Nle-CHO; GSII)

目录号: HY-120234
产品使用指南

摩尔计算器

Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) 是一种 γ-Secretase 抑制剂 I。Z-LLNle-CHO 通过阻断 Akt 介导的促生存途径并诱导 caspase 和 ROS 依赖性细胞凋亡。Z-LLNle-CHO 可用于癌症的研究，如乳腺癌和白血病。

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Custom Peptide Synthesis

Z-LLNle-CHO Chemical Structure

Z-LLNle-CHO Chemical Structure

CAS No. : 133407-83-7

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Z-LLNle-CHO 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].

体外研究
(In Vitro)

Z-LLNle-CHO (0-5 µM or 0-3 µM; 72 h) results in a dose-dependent decrease in cell viability/proliferation in six breast cancer cell lines[1].
Z-LLNle-CHO shows proteasome inhibitory activity, which contributes to cytotoxicity to MCF-7 cells[1].
Z-LLNle-CHO blocks Akt-mediated pro-survival pathways and induces caspase- and ROS-dependent cell apoptosis in Nalm6 and 697 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Z-LLNle-CHO 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells
Concentration: 0-5 µM (for MCF-7); 0-3 µM
Incubation Time: 72 h
Result: Inhibited MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells with ED50 values of 3.25, 2.5, 2.4, 1.8, 1.6, and 1.4 μM, respectively.

Apoptosis Analysis[2]

Cell Line: Precursor-B ALL cells
Concentration: 0-2.5 µM
Incubation Time: 18-24 h
Result: Induced cell apoptosis.
体内研究
(In Vivo)

Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)[2].
Dosage: 5 mg/kg
Administration: Subcutaneous injection; single daily for 12 days
Result: Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group.
分子量

475.62

Formula

C26H41N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Z-LLNle-CHO 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-LLNle-CHO133407-83-7Z-Leu-Leu-Nle-CHO GSIIγ-secretaseProteasomeApoptosisGamma secretaseMCF-7BT474T47DMDA-MB-231SKBR3MDA-MB-468 cellsprecursor-B ALLbreast cancerleukaemiaInhibitorinhibitorinhibit

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