2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. CAY10505

CAY10505 是一种有效的选择性 PI3Kγ 抑制剂，作用于神经元细胞，IC50 为 30 nM。

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CAY10505 Chemical Structure

CAY10505 Chemical Structure

CAS No. : 1218777-13-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥380
In-stock
5 mg ￥233
In-stock
10 mg ￥350
In-stock
25 mg ￥600
In-stock
50 mg ￥1050
In-stock
100 mg ￥1750
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

CAY10505 相关抗体

Top Publications Citing Use of Products

    CAY10505 purchased from MCE. Usage Cited in: Cell Death Dis. 2020 Jul 3;11(7):500.  [Abstract]

    The protein expression levels of PIK3CG, AKT, and p-AKT are measured by Western blot. The properties of EMT in SUM-1315 and ZR-75-1 transfected with CAY10505 is determined by wound healing assay.

    查看 PI3K 亚型特异性产品:

    查看所有亚型
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons.

    IC50 & Target[1]

    PI3Kγ

    30 nM (IC50, Neurons)

    体外研究
    (In Vitro)

    A class IB PI3Kγ isoform inhibitor CAY10505 at 200 nM (IC50=30 nM) partially reduces the baicalein-induced Akt phosphorylation in neurons[1]. The pharmacological PI3K inhibitor CAY10505 (PIK3CG) is tested on an extended panel of multiple myeloma (MM) cell lines and freshly isolated primary MM samples. MM cells are CAY10505-treated for 3 d (MM cell lines) or 5 d (primary MM cells) respectively, and survival is analysed by flow cytometry (annexin V-FITC/PI staining). Treatment of bone marrow stromal cells (BMSCs)-co-cultured primary MM samples with the PIK3CA inhibitor CAY10505 results in anti-survival effects (mean survival relative to DMSO-treated controls: CAY10505: 84±14%, tested at 10 μM)[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    CAY10505 相关抗体:
    体内研究
    (In Vivo)

    Administration of CAY10505 (0.6 mg/kg, p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly increases serum nitrite and (or) nitrate concentrations in hypertensive rats. Acetylcholine (ACh) and Sodium nitroprusside (SNP) produce endothelium-dependent and-independent relaxation in isolated rat aortic ring precontracted with Phenylephrine (3 μM), in a dose dependent manner. Administration of CAY10505 (0.6 mg/kg,p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly prevents hypertension-induced attenuation of ACh-induced endothelium-dependent relaxation. Deoxycorticosterone acetate salt (DOCA, 40 mg/kg, s.c.) induced hypertension markedly attenuates acetylcholine-induced endothelium-dependent relaxation, but does not affect SNP-induced endotheliumindependent relaxation[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    289.28

    Formula

    C14H8FNO3S
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : ≥ 34 mg/mL (117.53 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.4569 mL 17.2843 mL 34.5686 mL
    5 mM 0.6914 mL 3.4569 mL 6.9137 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.75%

    COA (194 KB) LCMS (266 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [2]

    Up to 5×104 multiple myeloma (MM) cells/100 μL of medium per well are seeded in 96-well-plates. Primary MM cells are always seeded into wells containing primary bone marrow stromal cells. Drugs (e.g., CAY10505) are dissolved in either DMSO or acidified ethanol (in the case of melphalan) and kept as frozen stock solutions of 10-50 mM. Working dilutions in fullmedium are always freshly prepared. In the case of Bortezomib small volumes of single-thaw stock solution aliquots are prepared. Drug dilutions (e.g., CAY10505, 2.5, 5, 7.5 and 10 μM) are added to MM cells as 100 μL of 2× the final concentration per well for single-drug treatments, and in appropriate volumes of higher concentrations for drug combinations. Solvent controls are always included[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [3]

    Rats[3]
    Wistar albino rats (180-240 g) of either sex are employed in the present study. For each group, the number of rats used (n) is 6. Group I (normal control): Rats are maintained on a diet of normal chow with drinking water. Group II (hypertensive control): Rats are unilaterally nephrectomized (uninephrectomised) and DOCA (40 mg/kg) is administered by subcutaneous injection (s.c.) twice weekly for 6 weeks, and then the untreated drinking water is replaced with a 1% NaCl solution. Group III (hypertensive rats): Rats are treated with CAY10505 (0.6 mg/kg, per os (p.o)) for 1 week after 5 weeks of treatment with DOCA. Group IV (hypertensive rats): Rats are treated with Losartan (25 mg/kg, p.o.) for 1 week after 5 weeks of treatment with DOCA. Group V (hypertensive rats): Rats are treated with Atorvastatin (30 mg/kg, p.o.) for 1 week after 5 weeks of treatment with DOCA.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    CAY10505 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.4569 mL 17.2843 mL 34.5686 mL 86.4215 mL
    5 mM 0.6914 mL 3.4569 mL 6.9137 mL 17.2843 mL
    10 mM 0.3457 mL 1.7284 mL 3.4569 mL 8.6421 mL
    15 mM 0.2305 mL 1.1523 mL 2.3046 mL 5.7614 mL
    20 mM 0.1728 mL 0.8642 mL 1.7284 mL 4.3211 mL
    25 mM 0.1383 mL 0.6914 mL 1.3827 mL 3.4569 mL
    30 mM 0.1152 mL 0.5761 mL 1.1523 mL 2.8807 mL
    40 mM 0.0864 mL 0.4321 mL 0.8642 mL 2.1605 mL
    50 mM 0.0691 mL 0.3457 mL 0.6914 mL 1.7284 mL
    60 mM 0.0576 mL 0.2881 mL 0.5761 mL 1.4404 mL
    80 mM 0.0432 mL 0.2161 mL 0.4321 mL 1.0803 mL
    100 mM 0.0346 mL 0.1728 mL 0.3457 mL 0.8642 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CAY105051218777-13-9CAY 10505CAY-10505PI3KApoptosisPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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    目录号：
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