1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. BMS-193885

BMS-193885 

目录号: HY-120619
产品使用指南

BMS-193885 是一种有效选择性、竞争性和脑渗透性的神经肽 Y1 受体拮抗剂,Ki 为 3.3 nM,对 hY1IC50 值为 5.9 nM,其选择性比 α1 受体高出100倍,比 hY2、hY4和hY5 受体高出 160 倍。

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BMS-193885 Chemical Structure

BMS-193885 Chemical Structure

CAS No. : 186185-03-5

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Description

BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].

IC50 & Target

Ki: 3.3 nM (Neuropeptide Y1 receptor)[1]
IC50: 5.9 nM (hY1)[1]

Molecular Weight

590.71

Formula

C₃₃H₄₂N₄O₆

CAS No.

186185-03-5

SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=C2)OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
BMS-193885
目录号:
HY-120619
需求量:

BMS-193885

Cat. No.: HY-120619