1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Buclizine dihydrochloride

Buclizine dihydrochloride 

目录号: HY-A0128A 纯度: >98.0%
产品使用指南

Buclizine dihydrochloride 是具有口服活性的抗组胺、抗过敏化合物。Buclizine dihydrochloride 对大鼠是一种强效的致畸剂。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Buclizine dihydrochloride Chemical Structure

Buclizine dihydrochloride Chemical Structure

CAS No. : 129-74-8

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
100 mg ¥500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat[1][2][3].

In Vitro

Buclizine (0-100 μM, 72 h) inhibits cancer cell growth by binding to TCTP and induction of cell differentiation[3].

Cell Proliferation Assay[3].

Cell Line: MCF-7 cells[3].
Concentration: 0-100 μM.
Incubation Time: 72 h.
Result: The IC50 was 19.18 ± 5.32 μM.
In Vivo

Buclizine dihydrochloride (≥40 mg/kg) exhibits teratogenic effect[1].
Buclizine dihydrochloride exhibits the t1/2 of ~10 h via oral administration[2].

Animal Model: Eighty-seven mature female rats weighing 240±20 grams[1].
Dosage: 30-200 mg/kg.
Administration: From days 10 to 15.
Result: Exhibits teratogenic effect dose-dependently when ≥40 mg/kg.
Molecular Weight

505.95

Formula

C₂₈H₃₅Cl₃N₂

CAS No.

129-74-8

SMILES

CC(C1=CC=C(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)C=C1)(C)C.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 2.5 mg/mL (4.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9765 mL 9.8824 mL 19.7648 mL
5 mM --- --- ---
10 mM --- --- ---
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BuclizineHistamine ReceptorantiallergichistamineTCTPInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Buclizine dihydrochloride
目录号:
HY-A0128A
需求量: