2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Carbonic Anhydrase HDAC
  4. CA/HDAC-IN-1

CA/HDAC-IN-1 (Compound 11) 是一种 CA 和 HDAC 抑制剂，对 hCA II、hCA IX 和 hCA XII 的 Ki 值分别为 7.4 nM、31.0 nM 和 7.3 nM，对 HDAC3 和 HDAC8 的 IC50 值分别为 0.21 μM 和 3.60 μM。CA/HDAC-IN-1 对结肠癌、乳腺癌和黑色素瘤具有抗癌活性。

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CA/HDAC-IN-1

CA/HDAC-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

CA/HDAC-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA IX CA XII

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CA/HDAC-IN-1 (Compound 11) is a CA and HDAC inhibitor with Ki values of 7.4 nM, 31.0 nM, and 7.3 nM for hCA II, hCA IX, and hCA XII, respectively, and IC50 values of 0.21 μM and 3.60 μM for HDAC3 and HDAC8, respectively. CA/HDAC-IN-1 has anti-cancer activity against colon cancer, breast cancer, and melanoma[1].

IC50 & Target[1]

hCA II

7.4 nM (Ki)

hCA XII

7.3 nM (Ki)

HDAC3

0.21 μM (IC50)

HDAC8

3.60 μM (IC50)

hCA IX

31.0 nM (Ki)

分子量

439.49

Formula

C21H21N5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CA/HDAC-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CA/HDAC-IN-1Carbonic AnhydraseHDACCarbonate dehydrataseHistone deacetylasesHCT-116MDA-MB-231BT-474A375501Meland Sk-Mel-28anti-cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-179271
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