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Carbazochrome 

目录号: HY-B1587 纯度: 99.19%
产品使用指南

Carbazochrome 是一种毛细管稳定剂,用于出血的研究。Carbazochrome 是一种抗出血剂。

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Carbazochrome Chemical Structure

Carbazochrome Chemical Structure

CAS No. : 69-81-8

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Size Price Stock Quantity
10 mM * 1 mL in Water ¥550 In-stock
250 mg ¥500 In-stock
500 mg   Get quote  
1 g   Get quote  

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Description

Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1].

In Vitro

Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner[1]. Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances[1].

In Vivo

Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2].

Animal Model: Male Sprague-Dawley rats weighing 180-230 g[2]
Dosage: 10 mg/kg
Administration: I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.).
Result: Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.
Molecular Weight

236.23

Formula

C₁₀H₁₂N₄O₃

CAS No.

69-81-8

中文名称

卡巴克络;卡络柳钠

SMILES

O=C1/C(C=C2C(O)CN(C)C2=C1)=N\NC(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (21.17 mM; ultrasonic and adjust pH to 12 with NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2332 mL 21.1658 mL 42.3316 mL
5 mM 0.8466 mL 4.2332 mL 8.4663 mL
10 mM 0.4233 mL 2.1166 mL 4.2332 mL
*

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储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

CarbazochromeOtherscapillarystabiliserhaemorrhageantihemorrhagicInhibitorinhibitorinhibit

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Carbazochrome
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HY-B1587
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