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  4. CRBN-6-5-5-VHL

CRBN-6-5-5-VHL 

目录号: HY-136262
产品使用指南

CRBN-6-5-5-VHL 是一种有效的选择性 cereblon (CRBN) 降解剂，DC50 值为 1.5 nM，而对底物 IKZF1 和 IKZF3 的降解几乎没有影响。

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CRBN-6-5-5-VHL Chemical Structure

CRBN-6-5-5-VHL Chemical Structure

CAS No. : 2362575-45-7

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

CRBN-6-5-5-VHL is a potent and selective cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3[1].

IC50 & Target[1]

Cereblon

1.5 nM (DC50)

Molecular Weight

972.20

Formula

C₅₁H₆₉N₇O₁₀S
CAS No.

2362575-45-7
SMILES

O=C(N1C(CCC2=O)C(N2)=O)C(C(C1=O)=CC=C3)=C3NCCCCCCOCCCCCOCCCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]4O)[C@@H](C4)C(NCC5=CC=C(C(SC=N6)=C6C)C=C5)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
References

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CRBN-6-5-5-VHLPROTACProteolysis-targeting chimeraVHLE3ligasesdegradationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-136262
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