1. Anti-infection
    Immunology/Inflammation
    Autophagy
  2. Parasite
    Toll-like Receptor (TLR)
    Autophagy
  3. Desethyl chloroquine diphosphate

Desethyl chloroquine diphosphate 

目录号: HY-135811A
产品使用指南

Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine diphosphate 具有抗疟原虫活性。

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Desethyl chloroquine diphosphate Chemical Structure

Desethyl chloroquine diphosphate Chemical Structure

CAS No. : 247912-76-1

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Description

Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].

IC50 & Target

P. falciparum[1]

In Vivo

Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3].

Molecular Weight

487.81

Formula

C₁₆H₂₈ClN₃O₈P₂

CAS No.

247912-76-1

SMILES

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC.O=P(O)(O)O.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Desethyl chloroquine diphosphateParasiteToll-like Receptor (TLR)AutophagyStereoselectivedesethylmetaboliteChloroquineP. falciparumantiplasmodicInhibitorinhibitorinhibit

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Desethyl chloroquine diphosphate
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HY-135811A
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