1. GPCR/G Protein Neuronal Signaling
  2. Opioid Receptor
  3. DIPPA hydrochloride

DIPPA (hydrochloride) 是一种不可逆、长效、选择性和高亲和力的 κ-opioid receptor 拮抗剂。DIPPA (hydrochloride)可用于焦虑和抗抑郁活性分子的研究。

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DIPPA hydrochloride Chemical Structure

DIPPA hydrochloride Chemical Structure

CAS No. : 155512-52-0

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规格 价格 是否有货 数量
5 mg ¥2846
3 - 4 周
10 mg ¥4558
3 - 4 周
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant[1][2][3][4].

IC50 & Target

κ Opioid Receptor/KOR

 

体内研究
(In Vivo)

DIPPA (2.5 and 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats[2].
DIPPA (1 and 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group[2].
DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 2.5 and 5 mg/kg
Administration: S.c.
Result: Decreased the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.
Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 1 and 5 mg/kg
Administration: S.c.
Result: High dose increased immobility in SD rats compared to the saline-treated strain control group.
分子量

484.87

Formula

C22H24Cl3N3OS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

DIPPA hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DIPPA hydrochloride
目录号:
HY-101223
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