2. MAPK/ERK Pathway NF-κB Stem Cell/Wnt Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. p38 MAPK NF-κB ERK JNK VEGFR MMP
  4. Emodic acid

Emodic acid(NSC624610) 是一种从 A. microcarpus 中分离出来的蒽醌类化合物，可以通过 NF-κB 的活性抑制，从而抑制癌细胞增殖。Emodic acid 也可以抑制 p38、ERK 和 JNK 的磷酸化，促肿瘤细胞因子 IL-1β 和 IL-6 的分泌，以及 VEGF 和 MMP 的表达，进而抑制癌细胞的侵袭和迁移潜能。

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Emodic acid

Emodic acid Chemical Structure

CAS No. : 478-45-5

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Emodic acid 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

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JNK1 JNK2 JNK3 JNK

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
> 10 μM
Compound: 10
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
[PMID: 28509552]
Jurkat IC50
> 10 μM
Compound: 10
Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Cytotoxicity against human Jurkat T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
[PMID: 28509552]
K562 IC50
> 10 μM
Compound: 10
Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
[PMID: 28509552]
体外研究
(In Vitro)

Emodic acid(0-100 μM, 72 h)表现出很强的抗增殖活性，在小鼠乳腺癌 4T1、MDA-231 和 MCF-7 细胞系中 IC50 值分别为 9.33、8.56、7.95 μM[1]。
Emodic acid (50 μM, 24 h)在 4T1 细胞系中，可以显著抑制 NF-κB 转录活性 80.75%，抑制 p65 的磷酸化，抑制 MMP-9 mRNA 的表达[1]。
Emodic acid(50 μM, 24 h) 可以抑制促肿瘤细胞因子 IL-1β 和 IL-6 的分泌，以及 VEGF 和 MMP 的表达，进而抑制 4T1 细胞的侵袭和迁移能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Emodic acid 相关抗体:
分子量

300.22

Formula

C15H8O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Emodic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emodic acid478-45-5NSC624610NSC 624610NSC-624610p38 MAPKNF-κBERKJNKVEGFRMMPNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesc-Jun N-terminal kinaseVascular endothelial growth factor receptorMatrix metalloproteinasesA. microcarpusp38migrationcancerInhibitorinhibitorinhibit

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