1. MAPK/ERK Pathway NF-κB Stem Cell/Wnt Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  2. p38 MAPK NF-κB ERK JNK VEGFR MMP
  3. Emodic acid

Emodic acid  (Synonyms: NSC624610)

目录号: HY-134000
产品使用指南

Emodic acid(NSC624610) 是一种从 A. microcarpus 中分离出来的蒽醌类化合物,可以通过 NF-κB 的活性抑制,从而抑制癌细胞增殖。Emodic acid 也可以抑制 p38ERKJNK 的磷酸化,促肿瘤细胞因子 IL-1β 和 IL-6 的分泌,以及 VEGFMMP 的表达,进而抑制癌细胞的侵袭和迁移潜能。

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Emodic acid Chemical Structure

Emodic acid Chemical Structure

CAS No. : 478-45-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].

体外研究
(In Vitro)

Emodic acid(0-100 μM, 72 h)表现出很强的抗增殖活性,在小鼠乳腺癌 4T1、MDA-231 和 MCF-7 细胞系中 IC50 值分别为 9.33、8.56、7.95 μM[1]
Emodic acid (50 μM, 24 h)在 4T1 细胞系中,可以显著抑制 NF-κB 转录活性 80.75%,抑制 p65 的磷酸化,抑制 MMP-9 mRNA 的表达[1]
Emodic acid(50 μM, 24 h) 可以抑制促肿瘤细胞因子 IL-1β 和 IL-6 的分泌,以及 VEGFMMP 的表达,进而抑制 4T1 细胞的侵袭和迁移能力[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

300.22

Formula

C15H8O7

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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