1. Membrane Transporter/Ion Channel GPCR/G Protein Neuronal Signaling Anti-infection
  2. Sodium Channel Dopamine Receptor SARS-CoV
  3. Fluphenazine

Fluphenazine  (Synonyms: 氟奋乃静)

目录号: HY-119980
产品使用指南

Fluphenazine 是一种有效且具有口服活性的吩噻嗪类多巴胺受体 (dopamine receptor) 拮抗剂。Fluphenazine 阻断神经元电压门控的钠离子通道 (sodium channels)。Fluphenazine 主要通过拮抗中边缘、黑质纹状体和下颌结节神经通路的突触后多巴胺-2 受体来发挥作用。Fluphenazine 可拮抗苯甲酸甲酯诱导的小鼠刻板咬伤,抑制小鼠攀爬行为。Fluphenazine 可用于研究精神病以及与糖尿病相关的疼痛性周围神经病变,并有抑制 SARS-CoV-2 的潜力。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 Fluphenazine dihydrochloride

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Fluphenazine Chemical Structure

Fluphenazine Chemical Structure

CAS No. : 69-23-8

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Fluphenazine 的其他形式现货产品:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].

IC50 & Target

Dopamine receptor, Sodium channels, SARS-CoV-2[1][2]

体内研究
(In Vivo)

Fluphenazine (1 mg/kg;IG,从妊娠第 6 天到第 15 天进行) 会导致怀孕小鼠畸形[5]
Fluphenazine (0.125-1 mg/kg;IP,单剂量) 拮抗哌醋甲酯引起的刻板啃咬, 显着抑制攀爬行为[6]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (injected with 60 mg/kg Methylphenidate)[6]
Dosage: 0.125, 0.25, 0.5, and 1 mg/kg
Administration: IP, single dosage
Result: Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
Animal Model: Mature female Swiss-Webster mice[5]
Dosage: 1 mg/kg
Administration: IG, treated from day 6 to day 15 of gestation
Result: Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
Clinical Trial
分子量

437.52

Formula

C22H26F3N3OS

CAS 号
中文名称

氟奋乃静癸EP杂质B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Fluphenazine
目录号:
HY-119980
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