1. Gene
  2. Acly - ATP citrate lyase Gene

Acly - ATP citrate lyase Gene

中文名称:ATP柠檬酸裂解酶

种属: Mus musculus

同用名: A730098H14Rik

基因 ID: 104112 | 基因类型: protein coding

关于 Acly

Chromosome 11: 100,367,179-100,418,826 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 283 orthologues and is associated with 2 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 333.), mammary gland adult (RPKM 298.7) and 24 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 柠檬酸合酶活性。预计参与乙酰辅酶A生物合成过程和羧酸代谢过程。预计在脂质代谢过程的上游或内部起作用。位于线粒体中。以多种结构表达,包括消化系统;泌尿生殖系统;神经系统;呼吸系统;和感觉器官。与人类 ACLY(ATP 柠檬酸裂解酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and carboxylic acid metabolic process. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACLY (ATP Citrate Lyase). [provided by Alliance of Genome Resources, Apr 2022]

Acly 基因产物(2)

mRNA Protein Name
NM_001199296.1 NP_001186225.1 ATP-citrate synthase isoform 1
NM_134037.3 NP_598798.1 ATP-citrate synthase isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP citrate synthase activity IDA
IDA: 通过直接分析推断
25450640 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15102471 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Acly 蛋白结构

PLN02235

PLN02235: cl42902 (0 - 418)

PLN02522

PLN02522: cl31895 (478 - 1083)

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  • 1091 a.a.
蛋白主名 其他名称

ATP-citrate synthase

ATP-citrate (pro-S-)-lyase

citrate cleavage enzyme

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acly NCBI NCBI:47