1. Gene
  2. Mmp2 - matrix metallopeptidase 2 Gene

Mmp2 - matrix metallopeptidase 2 Gene

中文名称:基质金属肽酶 2

种属: Mus musculus

同用名: GelA; Clg4a; MMP-2

基因 ID: 17390 | 基因类型: protein coding

关于 Mmp2

Chromosome 8: 93,553,919-93,580,048 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 73 phenotypes. Broad expression in mammary gland adult (RPKM 186.), subcutaneous fat pad adult (RPKM 13.) and 15 other tissues.


该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员,这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工,产生成熟的锌依赖性内肽酶,可水解胶原蛋白、明胶、层粘连蛋白、纤连蛋白和弹性蛋白。缺乏编码蛋白的小鼠表现出抑制血管生成和减弱人类多中心骨质溶解与关节炎的特征,包括骨骼和颅面发育异常。 [RefSeq 提供,2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]

Mmp2 基因产物(1)

mRNA Protein Name
NM_008610.3 NP_032636.1 72 kDa type IV collagenase preproprotein

Mmp2 蛋白结构


PG_binding_1: pfam01471 (69 - 96)


Peptidase_M10: pfam00413 (117 - 445)


FN2: smart00059 (225 - 273)


FN2: smart00059 (283 - 331)


FN2: smart00059 (341 - 389)


HX: cd00094 (467 - 661)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
蛋白主名 其他名称

72 kDa type IV collagenase

72 kDa gelatinase

72kD gelatinase

72kD type IV collagenase

72kDa gelatinase

72kDa type IV collagenase

gelatinase A

matrix metalloproteinase 2

重组 Mmp2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73810 MMP-2 Protein, Mouse (HEK293, His) P33434 (M409-C662) ≥95%


种属 基因名 来源 基因 ID
Homo sapiens Mmp2 NCBI NCBI:4313
Rattus norvegicus Mmp2 NCBI NCBI:81686