1. Membrane Transporter/Ion Channel
    Autophagy
  2. P2X Receptor
    Autophagy
  3. Indophagolin

Indophagolin 

目录号: HY-134807
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Indophagolin 是一种有效的含 indoline 的自噬 (autophagy) 抑制剂 (IC50 = 140 nM)。Indophagolin 拮抗嘌呤能受体P2X4、P2X1 和 P2X3,IC50 分别为 2.71、2.40 和 3.49 μM。Indophagolin 还拮抗 Gq 蛋白偶联的 P2Y4、P2Y6 和 P2Y11 受体(IC50s =3.4~15.4 μM)。Indophagolin 五羟色胺受体5-HT6 有较强的拮抗作用 (IC50=1.0 μM),对 5-HT1B、5-HT2B、5-HT4e 和 5-HT7 有中度拮抗作用。

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Indophagolin Chemical Structure

Indophagolin Chemical Structure

CAS No. : 1207660-00-1

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Description

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

In Vitro

Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

523.75

Formula

C₁₉H₁₅BrClF₃N₂O₃S

CAS No.

1207660-00-1

SMILES

O=S(C1=CC2=C(C=C1Br)CCN2C(C3CC3)=O)(NC4=CC=C(Cl)C(C(F)(F)F)=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

IndophagolinP2X ReceptorAutophagyP2XRsautophagosomeformationindoline-basedclassmembrane-boundInhibitorinhibitorinhibit

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目录号:
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