1. PROTAC Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  2. PROTACs EGFR
  3. MS9427 TFA

MS9427 TFA 是一种有效的 PROTAC EGFR 降解剂,对野生型 EGFR 和突变型 EGFR L858R 的 Kd 分别为 7.1 nM 和 4.3 nM。MS9427 TFA 通过泛素/蛋白酶体系统 (UPS) 和自噬/溶酶体途径选择性地降解突变体,但不降解WT EGFR。MS9427 TFA 对 NSCLC 细胞增殖有较强的抑制作用。MS9427 TFA 可用于抗癌研究。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

MS9427 TFA Chemical Structure

MS9427 TFA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥1600
In-stock
5 mg ¥4800
In-stock
10 mg ¥8000
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of MS9427 TFA:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS9427 TFA is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 TFA selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 TFA potently inhibits the proliferation of NSCLC cells. MS9427 TFA can be used for researching anticancer[1].

体外研究
(In Vitro)

MS9427 TFA 对 HCC-827 细胞具有抗增殖活性,GI50 为 0.87 ± 0.27 μM [1]
MS9427 TFA (0-10μM, 16 h) 有效诱导 EGFRdel19降解 (DC50=82 ± 73 nM),并在 HCC-827 细胞中以浓度依赖的方式抑制EGFR磷酸化(p-EGFR)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HCC-827 cells
Concentration: 1, 10, 50, 100, 200, 500, 100, and 10000 nM
Incubation Time: 16 h
Result: Inhibited EGFR phosphorylation (p-EGFR) in a concentration-dependent manner in HCC-827 cells.

Western Blot Analysis[1]

Cell Line: HCC-827 cells
Concentration: 100 nM
Incubation Time: 1, 2, 4, 6, 12, 24, 48 h
Result: Induced EGFR degradation in a time-dependent manner and through the UPS and autophagy/lysosome system.
分子量

1107.50

Formula

C50H59ClF4N8O14

性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
MS9427 TFA
目录号:
HY-147941A
需求量: