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  3. Oenothein B

Oenothein B  (Synonyms: 月见草素B)

目录号: HY-N7765
产品使用指南

Oenothein B 是一种二聚体大环鞣花单宁,具有广泛的药理活性,包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。

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Oenothein B Chemical Structure

Oenothein B Chemical Structure

CAS No. : 104987-36-2

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].

体外研究
(In Vitro)

Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1].
Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1].
Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1].
A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours
Result: Effectively inhibited the proliferation of A549 cells.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Induced apoptosis in A549 cells.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: Arrested cells in the G1 phase.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 15 µM, 30 µM and 45 µM
Incubation Time: 24 hours
Result: BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
体内研究
(In Vivo)

Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1569.08

Formula

C68H48O44

CAS 号
中文名称

月见草素B

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (79.66 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6373 mL 3.1866 mL 6.3732 mL
5 mM 0.1275 mL 0.6373 mL 1.2746 mL
查看完整储备液配制表
  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6373 mL 3.1866 mL 6.3732 mL 15.9329 mL
5 mM 0.1275 mL 0.6373 mL 1.2746 mL 3.1866 mL
10 mM 0.0637 mL 0.3187 mL 0.6373 mL 1.5933 mL
15 mM 0.0425 mL 0.2124 mL 0.4249 mL 1.0622 mL
20 mM 0.0319 mL 0.1593 mL 0.3187 mL 0.7966 mL
25 mM 0.0255 mL 0.1275 mL 0.2549 mL 0.6373 mL
30 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.5311 mL
40 mM 0.0159 mL 0.0797 mL 0.1593 mL 0.3983 mL
50 mM 0.0127 mL 0.0637 mL 0.1275 mL 0.3187 mL
60 mM 0.0106 mL 0.0531 mL 0.1062 mL 0.2655 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Oenothein B
目录号:
HY-N7765
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