1. Apoptosis
  2. Apoptosis
    IAP
  3. Polygalacin D

Polygalacin D 

目录号: HY-N6064
产品使用指南

Polygalacin D (PGD) 是从桔梗 Platycodon grandiflorum 中分离的具有抗癌和抗增殖特性的生物活性化合物。 Polygalacin D 抑制 IAP 蛋白家族的表达,包括存活蛋白,cIAP-1 和 cIAP-2 蛋白,并通过抑制 GSK3β,Akt 的磷酸化和PI3K 的表达来阻断 PI3K/Akt 途径。Polygalacin D 通过 PI3K/Akt 途径诱导凋亡 (apoptosis)。

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Polygalacin D Chemical Structure

Polygalacin D Chemical Structure

CAS No. : 66663-91-0

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Top Publications Citing Use of Products
  • 生物活性

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  • 参考文献

Description

Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]

IC50 & Target

IC50: IAP[1]

In Vitro

Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC50s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells[1].
Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1].
Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1].

Cell Proliferation Assay[1]

Cell Line: A549 and H460 cancer cell lines
Concentration: 10 µM, 20 µM, 40µM
Incubation Time: 48 hours
Result: Inhibited the proliferation of NSCLC cell lines.

Apoptosis Analysis[1]

Cell Line: A549 and H460 cancer cell lines
Concentration: 10 µM, 20 µM
Incubation Time: 48 hours
Result: Induced apoptosis of NSCLC cell lines.

Western Blot Analysis[1]

Cell Line: A549 and H460 cancer cell lines
Concentration: 10 µM, 20 µM
Incubation Time: 48 hours
Result: Decreased survivin, c-IAP-1 and c-IAP-2 expression.
Molecular Weight

1209.32

Formula

C₅₇H₉₂O₂₇

CAS No.

66663-91-0

SMILES

O[C@H]([C@@H]([C@@H](O[C@@]1([H])[C@@H]([C@H]([C@H](O)CO1)O[C@@]2([H])[C@@H]([C@](CO)(O)CO2)O)O)[C@H](C)O3)O)[C@]3([H])O[C@H]([C@H]([C@@H](O)CO4)O)[C@@H]4OC([C@]56[C@](CC(C)(C)CC6)([H])C7=CC[C@@]([C@@]8([C@@]([C@](C)([C@@H](O[C@]9([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]9O)CO)[C@@H](O)C8)CO)([H])CC%10)C)([H])[C@]%10(C)[C@]7(C)C[C@H]5O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
Polygalacin D
目录号:
HY-N6064
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Polygalacin D

Cat. No.: HY-N6064