2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt JAK/STAT Signaling Apoptosis Cell Cycle/DNA Damage
  3. SHP1 STAT Caspase Apoptosis Bcl-2 Family CDK Survivin
  4. SC-60

SC-60 是一种 Sorafenib (HY-10201) 衍生物。SC-60 通过激活 SHP-1 磷酸酶活性，进而抑制 STAT3 信号通路发挥抗肿瘤作用。SC-60 在多种肝细胞癌 (HCC) 细胞系中表现出强增殖抑制活性。SC-60 下调下游凋亡抑制蛋白 (如 Bcl-2、Cyclin D1、Survivin) 表达，最终诱导 caspase 依赖性凋亡 (apoptosis)。SC-60 在异种移植瘤模型中显著抑制肿瘤生长。SC-60 可用于研究 HCC。

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SC-60

SC-60 Chemical Structure

CAS No. : 1421677-31-7

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SC-60 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SC-60 is a derivative of Sorafenib (HY-10201). SC-60 exerts its anti-tumor effect by activating the phosphatase activity of SHP-1, thereby inhibiting the STAT3 signaling pathway. SC-60 exhibits strong proliferation inhibitory activity in various hepatocellular carcinoma (HCC) cell lines. SC-60 downregulates the expression of downstream anti-apoptotic proteins (such as Bcl-2, Cyclin D1, Survivin), ultimately inducing caspase-dependent apoptosis (apoptosis). SC-60 significantly inhibits tumor growth in xenograft tumor models. SC-60 can be used for the study of HCC[1].

IC50 & Target[1]

STAT3

 

Bcl-2

 

分子量

474.51

Formula

C29H22N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SC-60 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC-601421677-31-7SC60SC 60SHP1STATCaspaseApoptosisBcl-2 FamilyCDKSurvivinShp1PTPN6Src homology region 2 (SH-2) domain-containing phosphatase 1Cyclin dependent kinasesorafenib derivativedimer-based compoundhepatocellular carcinomaSHP-1 agonistSTAT3 signalingmolecular dockingxenograft modeldrug resistanceapoptosis inductionInhibitorinhibitorinhibit

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