Scopolamine hydrochloride  (Synonyms: (-)-Scopolamine hydrochloride; Hyoscine hydrochloride)

Scopolamine (Hyoscine) hydrochloride is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. Scopolamine hydrochloride competitively antagonizes 5-HT₃ receptors with an IC₅₀ of 2.09 μM. Scopolamine hydrochloride can induce cognitive and memory deficits in animals. Scopolamine hydrochloride can be used in the research of preventing postoperative nausea and vomiting, motion sickness, nervous system diseases, etc^{[1][2][3][4][5]}.

Scopolamine hydrochloride 阻断烟碱乙酰胆碱受体 (IC₅₀ = 928 μM)，并增加 α7 nACh 受体的表达。Scopolamine hydrochloride 与 0.6 nM [³H]Granisetron 呈浓度依赖性竞争作用，平均 pK_i 为 5.17 (K_i=6.76 μM)。Granisetron (HY-B0071) 荧光标记物 与 Scopolamine hydrochloride 进行浓度依赖性竞争，平均 pK_i 为 5.31 (K_i = 4.90 μM)。Scopolamine hydrochloride 可阻断毒蕈碱受体并诱发认知障碍^[1]。
Scopolamine (0.1-3 mM；作用 24 小时) hydrochloride 可诱导 SH-SY5Y 细胞的细胞毒性、活性氧 (ROS) 生成和凋亡^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

注意：
请勿仅参考一篇文章来确定实验条件。建议在正式实验前，通过预实验确定最佳实验条件 (动物品系、年龄、剂量、频率及周期、检测时间及指标等)。

Scopolamine (1 mg/kg；腹腔注射；一次) 可在小鼠中导致与胆碱能神经传递减弱相关的记忆障碍，并增加与脑内氧化应激相关的过程^[7]。
Scopolamine 可用于诱导记忆障碍模型^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

339.81

C₁₇H₂₂ClNO₄

55-16-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lochner M, et al. The muscarinic antagonists Scopolamine and atropine are competitive antagonists at 5-HT3 receptors. Neuropharmacology. 2016 Sep;108:220-8.  [Content Brief]

  [2]. O ET, et al. COGNITIVE-ENHANCING PROPERTIES OF MORINDA LUCIDA (RUBIACEAE) AND PELTOPHORUM PTEROCARPUM (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE. Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):136-141.  [Content Brief]

  [3]. Pattanashetti LA, et al. Evaluation of neuroprotective effect of Quercetin with Donepezil in Scopolamine-induced amnesia in rats. Indian J Pharmacol. 2017 Jan-Feb;49(1):60-64.  [Content Brief]

  [4]. Yadang FSA, et al. Scopolamine-Induced Memory Impairment in Mice: Neuroprotective Effects of Carissa edulis (Forssk.) Valh (Apocynaceae) Aqueous Extract. Int J Alzheimers Dis. 2020 Aug 31;2020:6372059.  [Content Brief]

  [5]. Klinkenberg I, et al. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev. 2010 Jul;34(8):1307-50.  [Content Brief]

  [6]. Nicha Puangmalai, et al. Neuroprotection of N-benzylcinnamide on scopolamine-induced cholinergic dysfunction in human SH-SY5Y neuroblastoma cells. Neural Regen Res. 2017 Sep;12(9):1492-1498.   [Content Brief]

  [7]. Barbara Budzynska, et al. Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice. Psychopharmacology (Berl). 2015 Mar;232(5):931-42.   [Content Brief]