2. 诱导疾病模型产品 GPCR/G Protein Neuronal Signaling
  3. 神经系统疾病模型 mAChR 5-HT Receptor
  4. 阿尔兹海默症模型
  5. Scopolamine hydrochloride

Scopolamine hydrochloride  (Synonyms: (-)-Scopolamine hydrochloride; Hyoscine hydrochloride)

目录号: HY-B2065
产品使用指南

摩尔计算器

Scopolamine hydrochloride 是一种非选择性和高亲和力的毒蕈碱（muscarinic） 拮抗剂。Scopolamine hydrochloride 可通过血脑屏障。Scopolamine hydrochloride 可逆地抑制 5-HT3 受体，IC50 为 2.09 μM。Scopolamine hydrochloride 可通过改变胆碱能系统诱导阿尔茨海默病样病理。

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Scopolamine hydrochloride Chemical Structure

Scopolamine hydrochloride Chemical Structure

CAS No. : 55-16-3

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Scopolamine hydrochloride 的其他形式现货产品:

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Other Forms of Scopolamine hydrochloride:

Scopolamine hydrochloride 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Scopolamine hydrochloride is a non-selective and high affinity (≤1 nM) muscarinic antagonist that is used for the prevention of post-operative nausea and vomiting. Scopolamine readily passes the blood brain barrier. Scopolamine also reversibly inhibits 5-HT3 receptor-responses with an IC50 of 2.09 μM[1]. Scopolamine induces Alzheimer's disease-like pathology through alteration of cholinergic system[2].

IC50 & Target[1]

5-HT3 Receptor

2.09 μM (IC50)

体外研究
(In Vitro)

Scopolamine blocks nicotinic acetylcholine receptors (IC50=928 μM) and increases the expression of α7 nACh receptors. Scopolamine displays concentration-dependent competition with 0.6 nM [3H]Granisetron, yielding an average pKi of 5.17±0.24 (Ki=6.76 μM). Concentration-dependent competition of fluorescently labeled form of granisetron (G-FL) with Scopolamine gives an average pKi of 5.31±0.09 (Ki=4.90 μM).Scopolamine blocks muscarinic receptors and induces a cognitive deficit[1].
Scopolamine (0.1-3 mM; for 24 hours) induces cytotoxicity, ROS generation and apoptosis of SH-SY5Y cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Scopolamine hydrochloride 相关抗体:

Cell Viability Assay[2]

Cell Line: Human neuroblastoma SH-SY5Y cell line
Concentration: 0.1-3 mM (usually 2 mM)
Incubation Time: 24 hours
Result: Exposure to 1-3 mM for 24 hours significantly decreased human neuroblastoma SH-SY5Y cell viability in a dose-dependent manner. In all subsequent experiments, 2 M resulted in 50.6±2.2% loss in cell viability.
体内研究
(In Vivo)

Scopolamine induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naive male Swiss mice weighing 20-25[3]
Dosage: 1 mg/kg
Administration: Administered intraperitoneally (i.p.); to measure the memory acquisition processes, Scopolamine was administered 20 min before the pretest; to measure the memory consolidation processes, Scopolamine was administered immediately after the pretest
Result: In scopolamine-treated group, there was a significant decrease in the index of latency (IL) value as compared with the saline-treated mice, indicating that scopolamine at the used dose impaired acquisition of memory and learning.
分子量

339.81

Formula

C17H22ClNO4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Scopolamine hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scopolamine55-16-3(-)-ScopolamineHyoscinemAChR5-HT ReceptorMuscarinic acetylcholine receptorSerotonin Receptor5-hydroxytryptamine ReceptorAlzheimerdiseaseacetylcholineapoptosisacetylcholinesteraseoxidativestressneuronal5-HT3MuscarinicAnxietyCognitionMemoryDepressionHippocampusAmygdalaInhibitorinhibitorinhibit

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