1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. SMAP-2

SMAP-2 (Synonyms: DT-1154)

目录号: HY-120272
产品使用指南

SMAP-2 (DT-1154) 是一种可口服生物利用的磷酸酶 2A (PP2A) 激活剂,绑定到支架亚基 PP2A Aα 上使 PP2A 构象变化。SMAP-2 (DT-1154) 能抑制 KRAS 突变肺癌的增长。

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SMAP-2 Chemical Structure

SMAP-2 Chemical Structure

CAS No. : 1809068-70-9

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Top Publications Citing Use of Products
  • 生物活性

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  • 参考文献

Description

SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].

IC50 & Target

PP2A[1]

Molecular Weight

532.57

Formula

C₂₇H₂₇F₃N₂O₄S

CAS No.

1809068-70-9

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@@H]2[C@@H](O)[C@H](N3C4=CC=CC=C4CCC5=CC=CC=C53)CCC2)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
SMAP-2
目录号:
HY-120272
需求量:

SMAP-2

Cat. No.: HY-120272