1. Immunology/Inflammation Anti-infection
  2. Toll-like Receptor (TLR) HIV
  3. Sparstolonin B

Sparstolonin B 作为选择性 TLR2TLR4 拮抗剂,选择性阻断 TLR2TLR4 介导的炎症信号传导。Sparstolonin B 具有抗 HIV 和抗癌活性。

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Sparstolonin B Chemical Structure

Sparstolonin B Chemical Structure

CAS No. : 1259330-61-4

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥3080
In-stock
1 mg ¥954
In-stock
5 mg ¥2100
In-stock
10 mg ¥3500
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25 mg ¥6500
In-stock
50 mg ¥9800
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100 mg   询价  
200 mg   询价  

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查看 Toll-like Receptor (TLR) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2].

IC50 & Target[1][2]

TLR2

 

TLR4

 

HIV-1

 

体外研究
(In Vitro)

Sparstolonin B (1-20 µM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells[3].
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2[1].
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells
Concentration: 1 µM, 5 µM, 10 µM or 20 µM
Incubation Time: 2-4 days
Result: Effectively and dose-dependently inhibits the viability of all neuroblastoma cell lines after 2 days (SH-SY5Y and IMR-32), 3 days (NGP cells) or 4 days (SKNF-1 and SK-N-BE(2) cells) treatment.
体内研究
(In Vivo)

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6-week-old male C57Bl/6 mice (body weight 18-20 g)[1]
Dosage: 100 μg/mouse
Administration: I.p.
Result: Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.
分子量

268.22

Formula

C15H8O5

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (37.28 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7283 mL 18.6414 mL 37.2828 mL
5 mM 0.7457 mL 3.7283 mL 7.4566 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: 0.5% CMC-Na/saline water

    Solubility: 5 mg/mL (18.64 mM); 悬浊液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.54%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7283 mL 18.6414 mL 37.2828 mL 93.2071 mL
5 mM 0.7457 mL 3.7283 mL 7.4566 mL 18.6414 mL
10 mM 0.3728 mL 1.8641 mL 3.7283 mL 9.3207 mL
15 mM 0.2486 mL 1.2428 mL 2.4855 mL 6.2138 mL
20 mM 0.1864 mL 0.9321 mL 1.8641 mL 4.6604 mL
25 mM 0.1491 mL 0.7457 mL 1.4913 mL 3.7283 mL
30 mM 0.1243 mL 0.6214 mL 1.2428 mL 3.1069 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Sparstolonin B
目录号:
HY-116213
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