1. Protein Tyrosine Kinase/RTK
    Cell Cycle/DNA Damage
    Autophagy
    Apoptosis
  2. VEGFR
    PDGFR
    IRE1
    Mitophagy
    Autophagy
    Apoptosis
  3. Sunitinib-d4

Sunitinib-d4 (Synonyms: 舒尼替尼 d4)

目录号: HY-10255AS1
产品使用指南

Sunitinib-d4 (SU 11248-d4) 是 Sunitinib 的氘代物。Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶抑制剂,抑制 VEGFR2PDGFRβIC50 分别为 80 nM 和 2 nM。Sunitinib 是ATP 竞争性抑制剂,可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制 Ire1α 的磷酸化。

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Sunitinib-d4 Chemical Structure

Sunitinib-d4 Chemical Structure

CAS No. : 1126721-79-6

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  • 参考文献

生物活性

Sunitinib-d4 (SU 11248-d4) is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

402.50

Formula

C22H23D4FN4O2

CAS 号
中文名称

舒尼替尼 d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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