Theophylline L-lysine  (Synonyms: Lysine theophyllinate)

Theophylline (L-lysine) (Lysine theophyllinate) is a soluble derivative of Theophylline (HY-B0809). Theophylline (L-lysine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (L-lysine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (L-lysine) has anti-inflammatory activity by increasing IL-10 and inhibiting NF-κB into the nucleus. Theophylline (L-lysine) induces apoptosis. Theophylline (L-lysine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research^{[1][2][3][4][5]}.

Theophylline (L-lysine) (1-1000 μM) 可通过 PDE 抑制支气管组织匀浆中cAMP 水解，从而使人体支气管和肺动脉舒张^[1]。
Theophylline (L-lysine) (10 μg/mL; 24 小时; 嗜酸性粒细胞) 可通过抑制抗凋亡蛋白 Bcl-2 来诱导细胞凋亡^[2]。
Theophylline (L-lysine) (0-500 μM; 2 小时; A549 细胞) 以浓度依赖的方式抑制 NF-κB 激活、IκBα 降解，并降低 IL-6 水平^[3]。
Theophylline (L-lysine) (0-1000 μM; 30 分钟; A549 细胞) 可通过诱导组蛋白去乙酰化酶的活性，从而降低炎症相关基因的表达^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Theophylline (L-lysine) (100 mg/kg; i.p.; 每天一次，持续 9 天; 雄性 Swiss 小鼠) 在小鼠体内具有抗炎活性，可升高 IL-6 和 IL-10 水平，并抑制 TNF-α 和 NO^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

326.35

C₁₃H₂₂N₆O₄

83920-54-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42.  [Content Brief]

  [2]. Németh ZH, et, al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7(5):371-5.  [Content Brief]

  [3]. Ichiyama T, et, al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):558-61.  [Content Brief]

  [4]. Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6.  [Content Brief]

  [5]. Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6.  [Content Brief]