1. Others TGF-beta/Smad Stem Cell/Wnt Neuronal Signaling Immunology/Inflammation GPCR/G Protein MAPK/ERK Pathway NF-κB Apoptosis
  2. Isotope-Labeled Compounds PKA Histamine Receptor p38 MAPK NF-κB TNF Receptor Interleukin Related
  3. Undecane-d24

Undecane-d24Undecane (HY-N8593) 的氘代物。Undecane 是一种强效 cAMP 激动剂,具有抗过敏和抗炎活性。Undecane 抑制脱颗粒以及组胺 (histamine) 和 TNF-α 的分泌。Undecane 可逆转 p38 磷酸化水平的升高、NF-κB 的转录活性以及靶细胞因子/趋化因子基因 (包括胸腺和活化调节趋化因子 (TARC)、巨噬细胞衍生趋化因子 (MDC) 和白细胞介素-8 (IL-8) 的升高。Undecane 可用于皮肤炎症性疾病的研究,如特应性皮炎。

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Undecane-d<sub>24</sub>

Undecane-d24 Chemical Structure

CAS No. : 164858-54-2

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生物活性

Undecane-d24 is the deuterium labeled Undecane (HY-N8593).Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis[1].

分子量

180.46

Formula

C11D24

CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Undecane-d24
目录号:
HY-N8593S
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