1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    GPCR/G Protein
  2. Phosphodiesterase (PDE)
    CXCR
  3. Zaprinast

Zaprinast (Synonyms: M&B 22948)

目录号: HY-B1816
产品使用指南

Zaprinast (M&B 22948) 是一种 cGMP 选择性的磷酸二酯酶 (PDE) 抑制剂。Zaprinast 是一种 GPR35 激动剂,对大鼠 GPR35 有很强的激活作用,对人 GPR35 有一定的激活作用。Zaprinast 能通过抗增殖和促凋亡作用减少血管重构。

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Zaprinast Chemical Structure

Zaprinast Chemical Structure

CAS No. : 37762-06-4

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Description

Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].

IC50 & Target

PDE[1], GPR35[2]

Molecular Weight

271.27

Formula

C₁₃H₁₃N₅O₂

CAS No.

37762-06-4

SMILES

O=C1C(N=NN2)=C2N=C(C3=CC=CC=C3OCCC)N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Zaprinast
目录号:
HY-B1816
需求量:

Zaprinast

Cat. No.: HY-B1816